Production of leukocytic pyrogen from phagocytes of neonates.
Production of leukocytic pyrogen from phagocytes of neonates.
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新生儿吞噬细胞产生白细胞热原。
DOI：
10.1093/infdis/144.4.337
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Wolff,SM
中科院分区：
文献类型：
--
作者：
Dinarello,CA;Shparber,M;KentJr,EF;Wolff,SM
为了研究新生儿发热的缺乏，我们在体外刺激新生儿脐带血白细胞产生白细胞热原（LP）。剖腹产出生的婴儿和母亲未经历自然分娩的婴儿的吞噬白细胞不产生LP或显著低于成人或自然分娩后出生的婴儿的白细胞。吞噬细胞产生LP的婴儿与不产生吞噬细胞的婴儿脐带血白细胞总数有显著差异。这一观察结果不能用麻醉剂、葡萄球菌的吞噬作用或产生LP的白细胞数量来解释；因此，他们认为在出生前产生LP的能力存在内在缺陷。令人感兴趣的是，人绒毛膜促性腺激素粗制剂中存在的一种不可透析物质明显抑制成人单核细胞LP的产生，但纯化的人绒毛膜促性腺激素没有影响。
To study the lack of feverduring the human newborn period, cord blood leukocytes obtained at birth were stimulated to produce leukocytic pyrogen(LP) in vitro. Phagocytic leukocytes from infants who were born by Caesarean section and whose mothers had not experienced natural onset of labor produced no LP or significantly less LP than leukocytes from adults or from infants born after natural onset of labor. There was a significant difference between total white blood cell count in cord blood of infants whose phagocytic cells produced LP and those whose cells did not. This observation could not be accounted for by anesthetic agents, phagocytosis of staphylococci, or number of leukocytes producing LP; thus, they suggest an intrinsic defect in the ability to produce LP before birth. Of interest is that a nondialyzable substance(s) present in crude preparations of human chorionicgonadotropin markedlysuppressed LP production from adult human monocytes, but purified human chorionicgonadotropin had no effect.
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成年和新生豚鼠的下丘脑对白细胞热原的敏感性。
DOI：
--
发表时间：
1979
期刊：
Journal of Physiology
影响因子：
--
作者：
C. Blatteis;K. A. Smith
通讯作者：
K. A. Smith
DOI：
--
发表时间：
1974
期刊：
Clinical science and molecular medicine
影响因子：
--
作者：
Q. Pittman;K. Cooper;W. Veale;G. V. van Petten
通讯作者：
G. V. van Petten
影响因子：
64.8
作者：
N. Kasting;W. Veale;K. Cooper
通讯作者：
K. Cooper
DOI：
10.1084/jem.150.3.709
发表时间：
1979-09-19
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Rosenwasser LJ;Dinarello CA;Rosenthal AS
通讯作者：
Rosenthal AS
新生儿和儿童的单核细胞亚群。
影响因子：
8
作者：
E. Arenson;M. B. Epstein;R. Seeger
通讯作者：
R. Seeger