Pancreatic carcinoma in perspective: A continuing challenge
Pancreatic carcinoma in perspective: A continuing challenge
复制标题
胰腺癌的视角：持续的挑战
作者：
H. Wanebo;M. Vezeridis
每年约有 27,000 例新发胰腺癌病例，大多数患者将死于该病。尽管吸烟是一个共同点，但慢性胰腺炎被认为是少数癌症的重要先兆病变。胰腺癌主要是胰管疾病。分子事件正在深入研究中，但约 80% 的病例涉及 c-K-ras 突变，p53 突变的程度略低 (60-80%)。早期表现通常是隐匿性的，但黄疸是胰头癌患者的常见表现。薄层计算机断层扫描、门静脉造影和内镜逆行胰胆管造影是目前最敏感的检测技术。超声内镜和腹腔镜检查的不断发展使用似乎可以增强检测能力，目前正在评估中。在许多患有晚期疾病的患者中，内窥镜旁路术可以消除不必要的手术，尽管某些患者仍然需要胃肠道旁路术（10-15%）。选定的患者（可能为 10-15%）可以进行根治性切除，在某些系列中预期生存期延长为 6->20%。生存差异可能与分期、患者选择和手术团队的专业知识有关。术前化疗/放疗正在研究中，可能会改善预后。参与临床试验对于改善治疗结果至关重要。癌症 1996；78：580‐91。
There are approximately 27,000 new cases of carcinoma of the pancreas each year and most afflicted patients will die of the disease. Although smoking is a common denominator, chronic pancreatitis is considered an important precursor lesion in a smaller number of cancers. Pancreatic cancer is primarily a disease of the pancreatic ducts. The molecular events are under intense study, but c‐K‐ras mutation is involved in approximately 80% of the cases and p53 to a slightly lesser degree (60–80%). Early manifestations are usually occult, but jaundice is a common manifestation in patients with cancers of the pancreatic head. Thin‐slice computed tomography, portography, and endoscopic retrograde cholangiopancreatography are currently the most sensitive detection techniques. The developing use of endoscopic ultrasound and laparoscopy appear to enhance detection and are under evaluation. In many patients with advanced disease, endoscopic bypass may eliminate the need for unnecessary surgery, although gastrointestinal bypass is still required in some patients (10–15%). Curative resection is possible in selected patients (perhaps 10–15%), with expectation of extended survival ranging from 6–>20% in some series. The survival differences may be related to stage, patient selection, and the expertise of the operative team. Preoperative chemotherapy/radiation is under study and may improve outcome. Clinical trial participation is essential for improvement in treatment outcomes. Cancer 1996;78:580‐91.
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咖啡和胰腺癌的流行病学。
影响因子：
11.2
作者：
Wynder,EL;Hall,NE;Polansky,M
通讯作者：
Polansky,M
DOI：
10.1093/jnci/76.1.49
发表时间：
1986
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
T. Mack;M. Yu;R. Hanisch;B. Henderson
通讯作者：
T. Mack;M. Yu;R. Hanisch;B. Henderson
影响因子：
11.2
作者：
A. Schally
通讯作者：
A. Schally
用 D-Trp-6-LH-RH 和生长抑素类似物 RC-160 微胶囊治疗叙利亚金仓鼠 N-亚硝基双（2-氧代丙基）胺诱导的胰腺癌。
影响因子：
11.2
作者：
Zalatnai,A;Schally,AV
通讯作者：
Schally,AV
烟草特异性和槟榔衍生的 N-亚硝胺在 F344 大鼠中诱导肺和外分泌胰腺肿瘤。
影响因子：
11.2
作者：
Rivenson,A;Hoffmann,D;Prokopczyk,B;Amin,S;Hecht,SS
通讯作者：
Hecht,SS