High S100A9(+) cell density predicts a poor prognosis in hepatocellular carcinoma patients after curative resection.
High S100A9(+) cell density predicts a poor prognosis in hepatocellular carcinoma patients after curative resection.
复制标题
DOI：
10.18632/aging.203162
复制
发表时间：
2021-06-22
期刊：
影响因子：
--
通讯作者：
Li L
中科院分区：
文献类型：
--
作者：
Liao J;Li JZ;Xu J;Xu Y;Wen WP;Zheng L;Li L
S100 A9在多种细胞类型中差异表达，并与多种癌症的发生、进展和转移相关。然而，S100 A9在肝细胞癌（HCC）中的表达、分布和临床意义尚不清楚。在本研究中，癌症基因组图谱（TCGA）数据库被用来检查S100 A9基因在HCC中的表达，我们发现S100 A9表达与HCC预后相关。此外，通过免疫组织化学分析382例HCC患者的组织来评估S100 A9蛋白表达。我们发现，在我们的组织芯片分析中，S100 A9+细胞在肿瘤和非肿瘤组织中的浸润可以预测较差的总生存率（P = 0.0329，肿瘤; P = 0.0003，非肿瘤）和高复发风险（P = 0.0387，肿瘤; P = 0.0015，非肿瘤）。免疫荧光双染显示癌旁组织中主要表达S100 A9的细胞为CD 15+中性粒细胞，而肝癌组织中CD 68+巨噬细胞和CD 15+中性粒细胞均表达S100 A9。总之，结果表明，高S100 A9+细胞密度预测HCC患者的预后不良，S100 A9表达可能作为HCC的独立预后标志物。
S100A9 is differentially expressed in various cell types and is associated with the development, progression and metastasis of various cancers. However, the expression, distribution, and clinical significance of S100A9 in hepatocellular carcinoma (HCC) remain unclear. In the present study, The Cancer Genome Atlas (TCGA) database was used to examine S100A9 gene expression in HCC; we found that S100A9 expression was associated with HCC prognosis. In addition, S100A9 protein expression was assessed by immunohistochemistry analysis of tissues from 382 HCC patients. We found that the infiltration of S100A9+ cells in both tumor and nontumor tissues could predict poor overall survival (P = 0.0329, tumor; P = 0.0003, nontumor) and a high recurrence risk (P = 0.0387, tumor; P = 0.0015, nontumor) in our tissue microarray analysis. Furthermore, immunofluorescence double staining revealed that the primary S100A9-expressing cells in adjacent nontumoral tissue were CD15+ neutrophils, and both CD68+ macrophages and CD15+ neutrophils expressed S100A9 in HCC tumor tissues. Taken together, the results suggest that high S100A9+ cell density predicts a poor prognosis in HCC patients, and S100A9 expression could potentially serve as an independent prognostic marker for HCC.
登录
查看更多内容
影响因子：
5.2
作者：
Hägglöf C;Bergh A
通讯作者：
Bergh A
HBx 诱导的 S100A9 以 NF-κB 依赖性方式促进肝细胞癌细胞的生长和转移。
影响因子：
9
作者：
Duan L;Wu R;Zhang X;Wang D;You Y;Zhang Y;Zhou L;Chen W
通讯作者：
Chen W
影响因子：
13.5
作者：
Nemeth, Julia;Stein, Ilan;Hess, Jochen
通讯作者：
Hess, Jochen
影响因子：
3.8
作者：
Nedjadi, Taoufik;Evans, Anthony;Costello, Eithne
通讯作者：
Costello, Eithne
影响因子：
9.7
作者：
De Ponti, Aurora;Wiechert, Lars;Angel, Peter
通讯作者：
Angel, Peter