Uterine Stem Cells and Benign Gynecological Disorders: Role in Pathobiology and Therapeutic Implications.
Uterine Stem Cells and Benign Gynecological Disorders: Role in Pathobiology and Therapeutic Implications.
复制标题
子宫干细胞与良性妇科疾病：在病理生物学和治疗意义中的作用。
DOI：
10.1007/s12015-020-10075-w
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发表时间：
2021-06
影响因子：
4.8
通讯作者：
Borahay M
中科院分区：
文献类型：
--
作者：
El Sabeh M;Afrin S;Singh B;Miyashita-Ishiwata M;Borahay M
子宫内膜和子宫肌层中的干细胞具有巨大的再生潜力，这是维持月经周期和支持妊娠所必需的。这些细胞，以及骨髓干细胞，也涉及到常见的良性妇科疾病，包括平滑肌瘤，子宫内膜异位症和子宫腺肌病的发展。目前的证据表明子宫干细胞转化为平滑肌瘤、子宫内膜异位症干细胞和子宫腺肌病干细胞中的肿瘤起始干细胞，获得每种良性疾病进展的遗传和表观遗传改变。在这篇全面的综述中，我们的目的是总结已经取得的进展，以表征干细胞参与良性妇科疾病的发病机制，尽管他们的巨大负担，尚未完全理解。我们专注于干细胞的特性和畸变，有助于良性妇科疾病的发展和可能的临床意义是什么已知的。最后，我们讨论了子宫干细胞在再生医学中的作用，特别是在治疗Asherman综合征中。
Stem cells in the endometrium and myometrium possess an immense regenerative potential which is necessary to maintain the menstrual cycle and support pregnancy. These cells, as well as bone marrow stem cells, have also been implicated in the development of common benign gynecological disorders including leiomyomas, endometriosis and adenomyosis. Current evidence suggests the conversion of uterine stem cells to tumor initiating stem cells in leiomyomas, endometriosis stem cells, and adenomyosis stem cells, acquiring genetic and epigenetic alterations for the progression of each benign condition. In this comprehensive review, we aim to summarize the progress that has been made to characterize the involvement of stem cells in the pathogenesis of benign gynecologic conditions that, despite their enormous burden, are not yet fully understood. We focus on the stem cell characteristics and aberrations that contribute to the development of benign gynecological disorders and the possible clinical implications of what is known so far. Lastly, we discuss the role of uterine stem cells in the setting of regenerative medicine, particularly in the treatment of Asherman syndrome.
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