Bone quality: understanding what matters.
Bone quality: understanding what matters.
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骨骼质量：了解重要的事情。
DOI：
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发表时间：
2004
影响因子：
1.9
通讯作者：
David B. Burr
中科院分区：
文献类型：
--
作者：
David B. Burr
尽管骨强度和骨折风险通常通过测量骨矿物质密度（BMD）来评估，但骨的机械性质实际上不仅由骨量决定，而且还由骨的结构/几何形状和组织的内在材料性质决定。骨折风险随着年龄的增长而增加，部分原因是BMD的变化。然而，75岁女性骨折的风险是45岁女性的4-7倍。这表明骨脆性有一个独立于骨量的成分，并由骨质决定。最近的观察结果强调了这一点，即骨质疏松症的抗吸收治疗都具有大致相同的骨折疗效，尽管它们对BMD的影响有7倍的差异。骨质量由至少四个因素定义：（1）骨转换速率;（2）胶原/矿物质基质的性质;（3）微损伤累积;（4）松质骨和皮质骨的结构/几何形状。
Although bone strength and fracture risk are generally assessed by measuring bone mineral density (BMD), the mechanical properties of bone are in fact determined not only by bone mass, but also by the architecture/geometry of the bone and by the intrinsic material properties of the tissue. Fracture risk increases with age, partly as a function of changes in BMD. However, the risk of fracture in a 75-yearold woman is 4-7 times that in a 45-year-old woman with an identical bone mass. This demonstrates that there is a component to bone fragility that is independent of bone mass, and determined by bone quality. This has been emphasized recently by the observation that anti-resorptive treatments for osteoporosis all have about the same fracture efficacy, though there is a seven-fold difference in their effect on BMD. Bone quality is defined by at least four factors: (1) the rate of bone turnover; (2) properties of the collagen/mineral matrix; (3) microdamage accumulation; (4) architecture/geometry of cancellous and cortical bone.
影响因子：
15.9
作者：
HUI, SL;SLEMENDA, CW;JOHNSTON, CC
通讯作者：
JOHNSTON, CC
影响因子：
4.1
作者：
Mashiba, T;Turner, CH;Burr, DB
通讯作者：
Burr, DB
影响因子：
4.1
作者：
Schaffler, MB;Choi, K;Milgrom, C
通讯作者：
Milgrom, C