AKR1C3 overexpression may serve as a promising biomarker for prostate cancer progression.
AKR1C3 overexpression may serve as a promising biomarker for prostate cancer progression.
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AKR1C3 过度表达可能作为前列腺癌进展的有前景的生物标志物
DOI：
10.1186/1746-1596-9-42
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发表时间：
2014-02-26
影响因子：
2.6
通讯作者：
Li J
中科院分区：
文献类型：
--
作者：
Tian Y;Zhao L;Zhang H;Liu X;Zhao L;Zhao X;Li Y;Li J
研究背景醛酮还原酶家族1成员C3（AKR 1C 3）是一种关键的类固醇生成酶，在前列腺癌（PCa）中过表达，与去势抵抗性前列腺癌（CRPC）的发生有关。本研究的目的是探讨AKR 1C 3的表达水平和PCa.MethodsSixty人前列腺穿刺活检组织标本和10 LNCaP异种移植物从完整的或去势雄性小鼠的进展之间的相关性。分析AKR 1C 3免疫组织化学表达水平与前列腺特异性抗原（PSA）、格里森评分（GS）和年龄等PCa进展评价因素的关系。结果正常前列腺上皮、良性前列腺增生（BPH）和前列腺上皮内瘤变（PIN）中AKR 1C 3免疫反应性较低。去势后，PCa上皮和LNCaP移植物中的阳性染色随着GS升高而逐渐增加。PCa活检组织中AKR 1C 3与GS和PSA水平的斯皮尔曼r值（rs）分别为0.396（P= 0.025）和-0.377（P= 0.036）。AKR 1C 3与年龄的相关系数为0.76（P= 0.011）。结论我们的研究表明AKR 1C 3表达水平与GS升高呈正相关，表明AKR 1C 3可以作为PCa进展的有希望的生物标志物。虚拟幻灯片本文的虚拟幻灯片可以在这里找到： http://www.diagnosticpathology.diagnomx.eu/vs/7748245591110149 .
BackgroundAldo-keto reductase family 1 member C3 (AKR1C3) is a key steroidogenic enzyme that is overexpressed in prostate cancer (PCa) and is associated with the development of castration-resistant prostate cancer (CRPC). The aim of this study was to investigate the correlation between the expression level of AKR1C3 and the progression of PCa.MethodsSixty human prostate needle biopsy tissue specimens and ten LNCaP xenografts from intact or castrated male mice were included in the study. The relationship between the level of AKR1C3 expression by immunohistochemistry and evaluation factors for PCa progression, including prostate-specific antigen (PSA), Gleason score (GS) and age, were analyzed.ResultsLow immunoreactivity of AKR1C3 was detected in normal prostate epithelium, benign prostatic hyperplasia (BPH) and prostatic intraepithelial neoplasia (PIN). Positive staining was gradually increased with an elevated GS in PCa epithelium and LNCaP xenografts in mice after castration. The Spearman’s r values (rs) of AKR1C3 to GS and PSA levels were 0.396 (P= 0.025) and -0.377 (P= 0.036), respectively, in PCa biopsies. Thersof AKR1C3 to age was 0.76 (P= 0.011). No statistically significant difference was found with other variables.ConclusionOur study suggests that the level of AKR.1C3 expression is positively correlated with an elevated GS, indicating that AKR1C3 can serve as a promising biomarker for the progression of PCa.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/7748245591110149 .
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