Abnormal Iron and Lipid Metabolism Mediated Ferroptosis in Kidney Diseases and Its Therapeutic Potential.
Abnormal Iron and Lipid Metabolism Mediated Ferroptosis in Kidney Diseases and Its Therapeutic Potential.
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DOI：
10.3390/metabo12010058
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发表时间：
2022-01-10
期刊：
影响因子：
4.1
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Zhang X;Li X
铁凋亡是一种新发现的由铁依赖性磷脂过氧化和氧化应激驱动的调节性细胞死亡形式。铁凋亡具有独特的生物学和形态学特征，例如与其他已知的受调节的细胞死亡相比，线粒体萎缩。铁凋亡的调控包括不同的分子机制和多种细胞代谢途径，包括谷胱甘肽/谷胱甘肽过氧化物酶4（GPX 4）信号通路，参与氨基酸代谢和GPX 4的激活;铁代谢信号通路，其通过铁调节蛋白（IRP）参与调节铁输入/输出和细胞内铁的储存/释放，和脂质代谢信号通路，其参与细胞膜中不饱和脂肪酸的代谢。铁凋亡在各种肾脏疾病的病理学中起重要作用，包括急性肾损伤（阿基）、慢性肾病（CKD）、常染色体显性多囊肾病（ADPKD）和肾细胞癌（RCC）。靶向铁凋亡及其诱导剂/引发剂和抑制剂可以调节动物模型中肾脏疾病的进展。在这篇综述中，我们讨论了铁凋亡的特点和基于铁凋亡的机制，突出了铁凋亡相关的主要代谢途径在各种肾脏疾病的治疗和预防中的潜在作用。
Ferroptosis is a newly identified form of regulated cell death driven by iron-dependent phospholipid peroxidation and oxidative stress. Ferroptosis has distinct biological and morphology characteristics, such as shrunken mitochondria when compared to other known regulated cell deaths. The regulation of ferroptosis includes different molecular mechanisms and multiple cellular metabolic pathways, including glutathione/glutathione peroxidase 4(GPX4) signaling pathways, which are involved in the amino acid metabolism and the activation of GPX4; iron metabolic signaling pathways, which are involved in the regulation of iron import/export and the storage/release of intracellular iron through iron-regulatory proteins (IRPs), and lipid metabolic signaling pathways, which are involved in the metabolism of unsaturated fatty acids in cell membranes. Ferroptosis plays an essential role in the pathology of various kidneys diseases, including acute kidney injury (AKI), chronic kidney disease (CKD), autosomal dominant polycystic kidney disease (ADPKD), and renal cell carcinoma (RCC). Targeting ferroptosis with its inducers/initiators and inhibitors can modulate the progression of kidney diseases in animal models. In this review, we discuss the characteristics of ferroptosis and the ferroptosis-based mechanisms, highlighting the potential role of the main ferroptosis-associated metabolic pathways in the treatment and prevention of various kidney diseases.
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影响因子：
64.5
作者：
Dixon SJ;Lemberg KM;Lamprecht MR;Skouta R;Zaitsev EM;Gleason CE;Patel DN;Bauer AJ;Cantley AM;Yang WS;Morrison B 3rd;Stockwell BR
通讯作者：
Stockwell BR
影响因子：
4
作者：
Dixon SJ;Winter GE;Musavi LS;Lee ED;Snijder B;Rebsamen M;Superti-Furga G;Stockwell BR
通讯作者：
Stockwell BR
影响因子：
19.6
作者：
AGARWAL, A;BALLA, J;NATH, KA
通讯作者：
NATH, KA
影响因子：
21.3
作者：
Friedmann Angeli JP;Schneider M;Proneth B;Tyurina YY;Tyurin VA;Hammond VJ;Herbach N;Aichler M;Walch A;Eggenhofer E;Basavarajappa D;Rådmark O;Kobayashi S;Seibt T;Beck H;Neff F;Esposito I;Wanke R;Förster H;Yefremova O;Heinrichmeyer M;Bornkamm GW;Geissler EK;Thomas SB;Stockwell BR;O'Donnell VB;Kagan VE;Schick JA;Conrad M
通讯作者：
Conrad M
影响因子：
2.9
作者：
Du Y;Zhao HC;Zhu HC;Jin Y;Wang L
通讯作者：
Wang L