Pathogenic Role of Epstein-Barr Virus in Lung Cancers.

Pathogenic Role of Epstein-Barr Virus in Lung Cancers.
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DOI:
10.3390/v13050877
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发表时间:
2021-05-11
期刊:
Viruses
影响因子:
--
通讯作者:
Lin Z
Lin Z
中科院分区:
其他
文献类型:
--
作者:
Becnel D;Abdelghani R;Nanbo A;Avilala J;Kahn J;Li L;Lin Z

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人类致癌病毒至少占全球癌症病例总数的12%。EB病毒(Epstein-Barr virus,EBV)是第一个被发现的人类致癌病毒,每年仅它就导致约20万例癌症病例和约1.8%的癌症相关死亡。在过去的40年里,越来越多的证据支持EBV感染与肺癌(LC)亚组之间的因果关系。在这篇文章中,我们回顾了目前的理解EB病毒与肺癌的关联和EB病毒在肺癌发生中的病因学作用。我们还讨论了从以前的研究中获得的知识的临床影响,挑战和未来的方向在这一领域。鉴于EBV-LC相关性的高度临床相关性,迫切需要对该主题进行进一步研究。
Human oncogenic viruses account for at least 12% of total cancer cases worldwide. Epstein–Barr virus (EBV) is the first identified human oncogenic virus and it alone causes ~200,000 cancer cases and ~1.8% of total cancer-related death annually. Over the past 40 years, increasing lines of evidence have supported a causal link between EBV infection and a subgroup of lung cancers (LCs). In this article, we review the current understanding of the EBV-LC association and the etiological role of EBV in lung carcinogenesis. We also discuss the clinical impact of the knowledge gained from previous research, challenges, and future directions in this field. Given the high clinical relevance of EBV-LC association, there is an urgent need for further investigation on this topic.
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发表时间: 2020-08-01
期刊: CANCERS
影响因子: 5.2
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