Single-walled carbon nanotube-based chemiresistive affinity biosensors for small molecules: ultrasensitive glucose detection.

Single-walled carbon nanotube-based chemiresistive affinity biosensors for small molecules: ultrasensitive glucose detection.
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DOI:
10.1021/ja100503b
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发表时间:
2010-04-14
影响因子:
15
通讯作者:
Mulchandani A
Mulchandani A
中科院分区:
化学1区
文献类型:
--
作者:
Cella LN;Chen W;Myung NV;Mulchandani A

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我们首次报道了基于单壁碳纳米管(SWNTs)的化学电阻亲和传感器,用于高灵敏度和选择性地使用置换格式检测小分子和/或弱/不带电分子。通过取代固定在单壁碳纳米管上的植物凝集素和葡聚糖来检测葡萄糖,具有比其他糖和人血清蛋白更高的皮摩尔灵敏度和选择性。
We report for the first time single wall carbon nanotubes (SWNTs)-based chemiresistive affinity sensors for highly sensitive and selective detection of small and/or weak-/un-charged molecules using displacement format. The detection of glucose, a small weakly charged molecule, by displacement of plant lectin, Concavalin A, bound to polysaccharide, dextran, immobilized on SWNTs, with picomolar sensitivity and selectivity over other sugars and human serum proteins is demonstrated as a proof-of-concept.
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