Anxiety Disorders are Associated with Reduced Heart Rate Variability: A Meta-Analysis.
Anxiety Disorders are Associated with Reduced Heart Rate Variability: A Meta-Analysis.
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焦虑症与心率变异性降低有关：荟萃分析。
DOI：
10.3389/fpsyt.2014.00080
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发表时间：
2014
影响因子：
4.7
通讯作者：
Kemp AH
中科院分区：
文献类型：
--
作者：
Chalmers JA;Quintana DS;Abbott MJ;Kemp AH
背景资料：焦虑症会增加未来心血管疾病（CVD）和死亡率的风险，即使在控制了包括吸烟，生活方式和社会经济地位在内的混淆因素后，也不考虑病史。虽然心率变异性（HRV）降低表明迷走神经功能受损可能是焦虑症与CVD相关的一种机制，但先前的研究报告了不一致的结果，强调了荟萃分析的必要性。方法：对以焦虑症为主要诊断的患者和健康对照者的静息状态HRV记录进行比较的研究被考虑用于荟萃分析。结果：荟萃分析基于36篇文章，包括2086例焦虑症患者和2294例对照。总体而言，焦虑症的特征是较低的HRV [高频（HF）：Hedges' g =-0.29。95%CI：−0.41至−0.17，p < 0.001;时域：Hedges' g = −0.45，95%CI：−0.57至−0.33，p < 0.001]。与对照组相比，惊恐障碍（n = 447）、创伤后应激障碍（n = 192）、广泛性焦虑障碍（n = 68）和社交焦虑障碍（n = 90），而非强迫症（n = 40），显示HF HRV降低（所有p < 0.001）。结论：焦虑症与HRV降低相关，结果与小到中等的效应量相关。研究结果对患者未来的身体健康和福祉具有重要意义，强调需要全面降低心血管风险。
Background: Anxiety disorders increase risk of future cardiovascular disease (CVD) and mortality, even after controlling for confounds including smoking, lifestyle, and socioeconomic status, and irrespective of a history of medical disorders. While impaired vagal function, indicated by reductions in heart rate variability (HRV), may be one mechanism linking anxiety disorders to CVD, prior studies have reported inconsistent findings highlighting the need for meta-analysis. Method: Studies comparing resting-state HRV recordings in patients with an anxiety disorder as a primary diagnosis and healthy controls were considered for meta-analysis. Results: Meta-analyses were based on 36 articles, including 2086 patients with an anxiety disorder and 2294 controls. Overall, anxiety disorders were characterized by lower HRV [high frequency (HF): Hedges’ g = −0.29. 95% CI: −0.41 to −0.17, p < 0.001; time domain: Hedges’ g = −0.45, 95% CI: −0.57 to −0.33, p < 0.001] than controls. Panic disorder (n = 447), post-traumatic stress disorder (n = 192), generalized anxiety disorder (n = 68), and social anxiety disorder (n = 90), but not obsessive–compulsive disorder (n = 40), displayed reductions in HF HRV relative to controls (all ps < 0.001). Conclusion: Anxiety disorders are associated with reduced HRV, findings associated with a small-to-moderate effect size. Findings have important implications for future physical health and well-being of patients, highlighting a need for comprehensive cardiovascular risk reduction.
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影响因子：
2.6
作者：
Bornas, Xavier;Llabres, Jordi;Vila, Irene
通讯作者：
Vila, Irene
影响因子：
8.8
作者：
Agelink, MW;Majewski, TB;Mueck-Weymann, M
通讯作者：
Mueck-Weymann, M
DOI：
10.1177/070674370304800604
发表时间：
2003-07-01
影响因子：
4
作者：
Baker, B;Khaykin, Y;Newman, D
通讯作者：
Newman, D
影响因子：
4
作者：
Billman GE
通讯作者：
Billman GE
影响因子：
4
作者：
Billman GE
通讯作者：
Billman GE