Development of antiviral therapy for severe acute respiratory syndrome.

Development of antiviral therapy for severe acute respiratory syndrome.
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DOI:
10.1016/j.antiviral.2005.03.002
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发表时间:
2005-06
期刊:
影响因子:
7.6
通讯作者:
Doerr HW
Doerr HW
中科院分区:
医学2区
文献类型:
--
作者:
Cinatl J Jr;Michaelis M;Hoever G;Preiser W;Doerr HW

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严重急性呼吸窘迫综合征(SARS)是由SARS冠状病毒(SARS-CoV)引起的一种新的疾病,于2003年初出现并迅速蔓延到全世界。虽然该疾病于2003年6月消失,但不能排除其重新出现的可能性。SARS冠状病毒疫苗的开发可能需要数年时间。因此,有效的抗SARS-CoV的抗病毒药物的可用性可能是控制未来SARS爆发的关键。本文就抗SARS药物的实验和临床研究进展进行综述。需要进行动物模型研究,以帮助确定哪些干预措施需要进行受控临床试验。
A new disease, the severe acute respiratory distress syndrome (SARS), caused by the SARS coronavirus (SARS-CoV), emerged at the beginning of 2003 and rapidly spread throughout the world. Although the disease had disappeared in June 2003 its re-emergence cannot be excluded. The development of vaccines against SARS-CoV may take years. Therefore, the availability of effective antiviral drugs against SARS-CoV may be crucial for the control of future SARS outbreaks. In this review, experimental and clinical data about potential anti-SARS drugs is summarised and discussed. Animal model studies will be needed to help to determine which interventions warrant controlled clinical testing.
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