Training the motor cortex by observing the actions of others during immobilization.
Training the motor cortex by observing the actions of others during immobilization.
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DOI：
10.1093/cercor/bht190
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发表时间：
2014-12
期刊：
影响因子：
--
通讯作者：
Fadiga L
中科院分区：
文献类型：
--
作者：
Bassolino M;Campanella M;Bove M;Pozzo T;Fadiga L
肢体制动和不使用是众所周知的皮质运动抑制的原因。虽然体能训练可以促进非使用依赖性皮质运动效应的恢复，但目前尚不清楚是否有可能以其他方式进入运动皮层，例如通过运动想象（MI）或动作观察（AO）。采用经颅磁刺激技术研究了正常人右手臂制动10 h前后手左侧运动皮层的兴奋性。在固定过程中，受试者被要求想象与他们的限制肢体或观察其他人的手的动作。第三组对照组观看电脑屏幕上播放的自然纪录片。手部皮质运动图和募集曲线可靠地表明，AO，而不是MI，防止制动引起的皮质运动抑制。我们的研究结果表明，在人类中存在的视觉机制，连接AO和执行，这是能够影响皮层可塑性的一个有益的方式。这种易化与动作模拟无关，因为它不是由外显MI引起的。
Limb immobilization and nonuse are well-known causes of corticomotor depression. While physical training can drive the recovery from nonuse-dependent corticomotor effects, it remains unclear if it is possible to gain access to motor cortex in alternative ways, such as through motor imagery (MI) or action observation (AO). Transcranial magnetic stimulation was used to study the excitability of the hand left motor cortex in normal subjects immediately before and after 10 h of right arm immobilization. During immobilization, subjects were requested either to imagine to act with their constrained limb or to observe hand actions performed by other individuals. A third group of control subjects watched a nature documentary presented on a computer screen. Hand corticomotor maps and recruitment curves reliably showed that AO, but not MI, prevented the corticomotor depression induced by immobilization. Our results demonstrate the existence of a visuomotor mechanism in humans that links AO and execution which is able to effect cortical plasticity in a beneficial way. This facilitation was not related to the action simulation, because it was not induced by explicit MI.
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