Traces of sub-Saharan and Middle Eastern lineages in Indian Muslim populations.
Traces of sub-Saharan and Middle Eastern lineages in Indian Muslim populations.
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DOI：
10.1038/ejhg.2009.168
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发表时间：
2010-03
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影响因子：
--
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中科院分区：
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--
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伊斯兰教是印度第二大宗教，仅次于印度教。目前还不清楚伊斯兰教在印度的传播仅仅是一种文化转变，还是与可检测到的基因流动有关。为了估计西亚和阿拉伯混合物对印度穆斯林的贡献，我们分别在472、431和476个样本中评估了mtDNA、Y染色体和LCT/MCM 6标记的遗传变异，这些样本代表了来自印度不同地理区域的6个穆斯林社区。我们发现，大多数印度穆斯林人口的主要遗传输入来自地理上接近的非穆斯林人口。然而，在印度穆斯林中也观察到低水平的可能的阿拉伯和西亚混合物，以L0 a2 a2 mtDNA和E1 b1 b1 a和J*（xJ 2）Y染色体谱系的形式存在。伊朗和阿拉伯来源之间的区别是很难与mtDNA和Y染色体的估计是高度相关的，由于类似的基因库组成的来源。相比之下，LCT/MCM 6基因座，这表明了两个来源之间的明显区别，使我们能够排除显着的基因流从阿拉伯半岛。总的来说，我们的研究结果支持一个模型，根据该模型，伊斯兰教在印度的传播主要是文化转换与轻微的，但仍然可以检测到的基因流从外部，主要是从伊朗和中亚，而不是直接从阿拉伯半岛。
Islam is the second-most practiced religion in India, next to Hinduism. It is still unclear whether the spread of Islam in India has been only a cultural transformation or was associated with detectable levels of gene flow. To estimate the contribution of West Asian and Arabian admixture to Indian Muslims we have assessed genetic variation in mtDNA, Y-chromosomal and LCT/MCM6 markers in 472, 431 and 476 samples, respectively, representing six Muslim communities from different geographical regions of India. We found that most of the Indian Muslim populations received their major genetic input from geographically close non-Muslim populations. However, low levels of likely Arabian and West Asian admixture were also observed among Indian Muslims in the form of L0a2a2 mtDNA and E1b1b1a and J*(xJ2) Y-chromosomal lineages. The distinction between Iranian and Arabian sources was difficult to make with mtDNA and the Y chromosome as the estimates were highly correlated due to similar gene pool compositions in the sources. In contrast, the LCT/MCM6 locus, which shows a clear distinction between the two sources, enabled us to rule out significant gene flow from Arabia. Overall, our results support a model according to which the spread of Islam in India was predominantly cultural conversion associated with minor but still detectable levels of gene flow from outside, primarily from Iran and Central Asia, rather than directly from the Arabian Peninsula.
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影响因子：
2.8
作者：
BALGIR, RS;SHARMA, JC
通讯作者：
SHARMA, JC
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9.2
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5.3
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通讯作者：
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