The Role of γδ T-Lymphocytes in Glioblastoma: Current Trends and Future Directions.
The Role of γδ T-Lymphocytes in Glioblastoma: Current Trends and Future Directions.
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DOI：
10.3390/cancers15245784
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发表时间：
2023-12-10
期刊：
影响因子：
5.2
通讯作者：
Rincon-Torroella, Jordina
中科院分区：
文献类型：
--
作者：
Ahmedna, Taha;Khela, Harmon;Weber-Levine, Carly;Azad, Tej D.;Jackson, Christopher M.;Gabrielson, Kathleen;Bettegowda, Chetan;Rincon-Torroella, Jordina
胶质母细胞瘤是最具侵袭性的脑肿瘤之一，具有较差的生存率和早期复发率。有效的免疫疗法治疗的发展受到这些肿瘤的抗浸润和免疫抑制肿瘤微环境的限制。γδ T细胞是非常规T细胞，其具有通过其对胶质母细胞瘤细胞上的分子靶标的独特识别来克服这些挑战的潜力。然而，在利用这些细胞方面存在挑战，包括它们的分离、扩增和促肿瘤活性的潜力。本文综述了γδ T细胞的生物学特性及其在胶质母细胞瘤免疫治疗中的作用，并提出了今后的研究方向。胶质母细胞瘤（GBM）的细胞免疫治疗由于肿瘤微环境（TME）的抗浸润性和免疫抑制性而面临重大挑战。γδ T细胞，表达特征性γδ T细胞受体的非常规T细胞，已经证明有希望克服这些挑战，表明具有巨大的免疫潜力。本文综述了γδ T细胞在GBM中的作用，并提出了未来研究的几个方向。使用PubMed、ScienceDirect和JSTOR数据库，我们对研究γδ T细胞生物学及其在GBM治疗中作用的文献进行了综述。我们确定了15项研究集中在人GBM中的γδ T细胞。浸润性γδ T细胞可以在某些TME中激发抗肿瘤免疫应答，尽管快速肿瘤进展和TME缺氧可能影响肿瘤抑制的程度。在这些研究中，现有结果显示了强效抗肿瘤活性的潜力和促肿瘤活性的风险。虽然γδ T细胞具有作为针对GBM的治疗剂的潜力，但是提取、分离和扩增γδ T细胞的技术挑战以及抗肿瘤级联与促肿瘤级联的激活仍然是其应用的障碍。克服这些限制可能会将γδ T细胞转化为GBM中有希望的免疫疗法。
Glioblastoma is one of the most aggressive brain tumors, with poor survival and early recurrence rates. The development of effective immunotherapy treatments has been limited by the infiltration-resistant and immunosuppressive tumor microenvironments of these tumors. γδ T cells are unconventional T cells that have the potential to overcome these challenges through their unique recognition of molecular targets on glioblastoma cells. Nonetheless, challenges exist in the utilization of these cells, including their isolation, expansion, and potential for protumor activity. In this review, we discuss the biology of γδ T cells and their role in immunotherapy for glioblastoma and propose several research avenues for future studies. Cell-based immunotherapy for glioblastoma (GBM) encounters major challenges due to the infiltration-resistant and immunosuppressive tumor microenvironment (TME). γδ T cells, unconventional T cells expressing the characteristic γδ T cell receptor, have demonstrated promise in overcoming these challenges, suggesting great immunotherapeutic potential. This review presents the role of γδ T cells in GBM and proposes several research avenues for future studies. Using the PubMed, ScienceDirect, and JSTOR databases, we performed a review of the literature studying the biology of γδ T cells and their role in GBM treatment. We identified 15 studies focused on γδ T cells in human GBM. Infiltrative γδ T cells can incite antitumor immune responses in certain TMEs, though rapid tumor progression and TME hypoxia may impact the extent of tumor suppression. In the studies, available findings have shown both the potential for robust antitumor activity and the risk of protumor activity. While γδ T cells have potential as a therapeutic agent against GBM, the technical challenges of extracting, isolating, and expanding γδ T cells, and the activation of antitumoral versus protumoral cascades, remain barriers to their application. Overcoming these limitations may transform γδ T cells into a promising immunotherapy in GBM.
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影响因子：
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作者：
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影响因子：
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