Regional differences in the coupling between resting cerebral blood flow and metabolism may indicate action preparedness as a default state.
Regional differences in the coupling between resting cerebral blood flow and metabolism may indicate action preparedness as a default state.
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DOI：
10.1093/cercor/bhn087
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发表时间：
2009-02
期刊：
影响因子：
3.7
通讯作者：
Gur, Raquel E.
中科院分区：
文献类型：
--
作者：
Gur, Ruben C.;Ragland, J. Daniel;Reivich, Martin;Greenberg, Joel H.;Alavi, Abass;Gur, Raquel E.
虽然大多数功能性神经影像学研究都是检查任务的影响，但人们对“默认”休息的大脑的兴趣却越来越大。休息条件下显示一致的区域活动，但氧提取分数恒定跨区域。我们比较了静息脑葡萄糖代谢率（CMRgl）测量18 F-标记的2-氟-2-脱氧-D-葡萄糖脑血流量（CBF）15 O-H2O措施，使用相同的正电子发射断层扫描仪在2个样本（n = 60和30）的健康右利手成人。计算35个标准感兴趣区域的区域与全脑比率，并在CBF和CMRgl之间进行比较以确定相对于代谢的灌注。初级视觉和听觉区域显示CBF和CMRgl之间的耦合，边缘和皮质下区域-基底节，丘脑和后颅窝结构-高灌注，而联合皮质低灌注。高灌注在左半球高于右半球的大多数皮质和胼胝体下边缘区，但对称的扣带回，基底节和躯体运动区。高灌注区域可能是那些预期在短时间内激活的区域，而下游皮质调节区域具有较长的部署“前置时间”。CBF和CMRgl系统解偶联的新观察可能有助于阐明“默认”静息状态的潜在生物学意义。左半球过度灌注是否反映了外侧优势需要进一步检查。
Although most functional neuroimaging studies examine task effects, interest intensifies in the “default” resting brain. Resting conditions show consistent regional activity, yet oxygen extraction fraction constancy across regions. We compared resting cerebral metabolic rates of glucose (CMRgl) measured with 18F-labeled 2-fluoro-2-deoxy-D-glucose to cerebral blood flow (CBF) 15O-H2O measures, using the same positron emission tomography scanner in 2 samples (n = 60 and 30) of healthy right-handed adults. Region to whole-brain ratios were calculated for 35 standard regions of interest, and compared between CBF and CMRgl to determine perfusion relative to metabolism. Primary visual and auditory areas showed coupling between CBF and CMRgl, limbic and subcortical regions—basal ganglia, thalamus and posterior fossa structures—were hyperperfused, whereas association cortices were hypoperfused. Hyperperfusion was higher in left than right hemisphere for most cortical and subcallosal limbic regions, but symmetric in cingulate, basal ganglia and somatomotor regions. Hyperperfused regions are perhaps those where activation is anticipated at short notice, whereas downstream cortical modulatory regions have longer “lead times” for deployment. The novel observation of systematic uncoupling of CBF and CMRgl may help elucidate the potential biological significance of the “default” resting state. Whether greater left hemispheric hyperperfusion reflects lateral dominance needs further examination.
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影响因子：
5.3
作者：
Aguilar, JR;Castro-Alamancos, MA
通讯作者：
Castro-Alamancos, MA
影响因子：
2.5
作者：
Iidaka, T;Matsumoto, A;Sadato, N
通讯作者：
Sadato, N
影响因子：
1.7
作者：
Goldstein, RZ;Volkow, ND;Gur, RC
通讯作者：
Gur, RC
影响因子：
25
作者：
Damasio, AR;Grabowski, TJ;Hichwa, RD
通讯作者：
Hichwa, RD
DOI：
10.1073/pnas.83.4.1140
发表时间：
1986-02-01
影响因子：
11.1
作者：
FOX, PT;RAICHLE, ME
通讯作者：
RAICHLE, ME