Continuing genomic evolution of the Neisseria meningitidis cc11.2 urethritis clade, NmUC: a narrative review.
Continuing genomic evolution of the Neisseria meningitidis cc11.2 urethritis clade, NmUC: a narrative review.
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DOI：
10.1099/mgen.0.001113
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发表时间：
2023-10
影响因子：
3.9
通讯作者：
Stephens DS
中科院分区：
文献类型：
--
作者：
Rodriguez EI;Tzeng YL;Stephens DS
脑膜炎奈瑟菌是一种导致侵袭性脑膜炎球菌病的细菌病原体。尽管通常在鼻咽部定植，但2015-2016年首次报道了脑膜炎球菌性尿道炎的多次爆发；最初被认为是淋病奈瑟菌（Ng）引起的疫情。基因组分析显示，引起这些暴发的Nm分离株是一个独特的分支，并且在多个基因组位点整合了淋球菌DNA，包括淋球菌反硝化装置aniA-norB，包含ispD的5个基因的部分淋球菌操纵子，以及与相邻淋球菌位点NGO0843的乙酰谷氨酸激酶基因argB。尿道炎分离株还缺失了C组胶囊生物合成基因cssA/B/C和csc，导致胶囊丢失。总的来说，这些分离物形成脑膜炎奈瑟菌尿道炎分支（NmUC）。近期（2016-2022）NmUC分离株的基因组分析显示，这些基因组特征在进化支系中保持不变，这意味着它们对NmUC作为泌尿生殖器病原体的地位很重要。此外，分析还揭示了一个亚分支的出现，称为NmUC-B，在系统发育上与早期的NmUC-A分离。这一亚进化支将其他淋球菌等位基因整合到基因组中，包括与抗菌素耐药性相关的等位基因。NmUC继续适应尿道生态位并演变为泌尿生殖系统病原体。
Neisseria meningitidis (Nm) is a bacterial pathogen responsible for invasive meningococcal disease. Though typically colonizing the nasopharynx, multiple outbreaks of meningococcal urethritis were first reported in 2015–2016; outbreaks originally presumed to be caused by Neisseria gonorrhoeae (Ng). Genomic analysis revealed that the Nm isolates causing these outbreaks were a distinct clade, and had integrated gonococcal DNA at multiple genomic sites, including the gonococcal denitrification apparatus aniA–norB, a partial gonococcal operon of five genes containing ispD, and the acetylglutamate kinase gene argB with the adjacent gonococcal locus NGO0843. The urethritis isolates had also deleted the group C capsule biosynthesis genes cssA/B/C and csc, resulting in loss of capsule. Collectively, these isolates form the N. meningitidis urethritis clade (NmUC). Genomic analysis of recent (2016–2022) NmUC isolates revealed that the genomic features have been maintained in the clade, implying that they are important for NmUC’s status as a urogenital pathogen. Furthermore, the analysis revealed the emergence of a sub-clade, designated NmUC-B, phylogenetically separated from the earlier NmUC-A. This sub-clade has integrated additional gonococcal alleles into the genome, including alleles associated with antimicrobial resistance. NmUC continues to adapt to a urethral niche and evolve as a urogenital pathogen.
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开放式细菌种群基因组学：BIGSDB软件，pubmlst.org网站及其应用。
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作者：
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