Disruption of ripple-associated hippocampal activity during rest impairs spatial learning in the rat.
Disruption of ripple-associated hippocampal activity during rest impairs spatial learning in the rat.
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DOI：
10.1002/hipo.20707
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发表时间：
2010-01
期刊：
影响因子：
3.5
通讯作者：
Wilson, Matthew A.
中科院分区：
文献类型：
--
作者：
Ego-Stengel, Valerie;Wilson, Matthew A.
海马体在获取关于地点和事件的新记忆中起着关键作用。有证据表明，这些记忆的巩固在睡眠中得到加强。在神经元水平上，在慢波睡眠的特征——锐波波纹事件中，海马清醒经验的再激活被认为是睡眠依赖性记忆巩固的一种神经机制。然而，睡眠再激活和记忆巩固之间的因果关系尚未确立。在这里，我们表明在涟漪事件中破坏神经元活动会损害空间学习。我们每天训练大鼠进行两个相同的空间导航任务，每个任务之后休息一小时。在其中一项任务后，海马事件的刺激选择性地破坏了与涟漪事件相关的神经元活动，而不改变睡眠-觉醒结构。大鼠学习控制任务的速度明显快于休息刺激后的任务，这表明在睡眠期间干扰海马加工导致学习能力下降。
The hippocampus plays a key role in the acquisition of new memories for places and events. Evidence suggests that the consolidation of these memories is enhanced during sleep. At the neuronal level, reactivation of awake experience in the hippocampus during sharp-wave ripple events, characteristic of slow-wave sleep, has been proposed as a neural mechanism for sleep-dependent memory consolidation. However, a causal relation between sleep reactivation and memory consolidation has not been established. Here we show that disrupting neuronal activity during ripple events impairs spatial learning. We trained rats daily in two identical spatial navigation tasks followed each by a one-hour rest period. After one of the tasks, stimulation of hippocampal afferents selectively disrupted neuronal activity associated with ripple events without changing the sleep-wake structure. Rats learned the control task significantly faster than the task followed by rest stimulation, indicating that interfering with hippocampal processing during sleep led to decreased learning.
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影响因子：
16.2
作者：
Lubenov, Evgueniy V.;Siapas, Athanassios G.
通讯作者：
Siapas, Athanassios G.
影响因子：
25
作者：
Ji, Daoyun;Wilson, Matthew A.
通讯作者：
Wilson, Matthew A.
影响因子：
2.9
作者：
BUZSAKI, G
通讯作者：
BUZSAKI, G
大鼠海马中内部生成的细胞组装序列。
影响因子：
56.9
作者：
Pastalkova, Eva;Itskov, Vladimir;Amarasingham, Asohan;Buzsaki, Gyoergy
通讯作者：
Buzsaki, Gyoergy
影响因子：
3.2
作者：
Plihal, W;Born, J
通讯作者：
Born, J