Association between Serum Uric Acid and Impaired Endothelial Function: The Circulatory Risk in Communities Study.
Association between Serum Uric Acid and Impaired Endothelial Function: The Circulatory Risk in Communities Study.
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DOI：
10.5551/jat.63199
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发表时间：
2022-10-01
影响因子：
4.4
通讯作者：
Iso H
中科院分区：
文献类型：
--
作者：
Tang J;Liu K;Eshak ES;Cui R;Sakaniwa R;Imano H;Dong JY;Iso H
目的：高尿酸血症可能损害血管内皮功能。然而，以人群为基础的证据检查血清UA水平和内皮功能之间的关系仍然是有限的。因此，在这项研究中，我们的目的是在一般人群中调查这一点。 研究方法：在这项横断面研究中，1000名参与者（496名男性和504名女性），年龄30-79岁，无痛风病史，接受了血清UA和肱动脉血流介导的扩张（FMD）测量。根据血清UA四分位数将参与者分为四组。根据血清UA水平，采用Logistic回归模型计算低FMD的比值比（OR）。 结果：总共有203名参与者（138名男性和65名女性），%FMD ≤ 5.0%，被确定为内皮功能障碍。最高四分位数与最低四分位数的低FMD的多变量OR为2.39（95%置信区间[CI]：1.32-4.34），而每1个标准差（SD）增量的OR为1.28（95% CI：1.04-1.56）。与男性相比，女性中的正相关性更明显（OR/1-SD增量：1.46; 95% CI：1.08-1.96），仅限于未使用抗高血压药物的个体。在使用降压药物的个体中，每1-SD增量的OR为1.01（95% CI：0.68-1.50），在未使用降压药物的个体中为1.43（95% CI：1.12-1.81）。 结论：在日本普通人群样本中，较高的血清UA与内皮功能障碍的患病率呈正相关，且该正相关仅限于未使用抗高血压药物的个体。
Aims: Higher serum uric acid (UA) may impair endothelial function. However, population-based evidence examining the association between serum UA levels and endothelial function remains to be limited. Thus, in this study, we aimed to investigate this in the general population. Methods: In this cross-sectional study, 1000 participants (496 males and 504 females), aged 30–79 years, free from a history of gout, have undergone both serum UA and brachial artery flow-mediated dilation (FMD) measurements. Participants were divided into four groups based on serum UA quartiles. Logistic regression models were used to calculate odds ratios (ORs) for low FMD according to the serum UA levels. Results: In total, 203 participants (138 males and 65 females) with %FMD ≤ 5.0% were identified to have endothelial dysfunction. The multivariable OR of low FMD for highest quartiles vs. lowest quartiles was 2.39 (95% confidence interval [CI]: 1.32–4.34), while OR per 1-standard deviation (SD) increment was 1.28 (95% CI: 1.04–1.56). The positive association was noted to be more evident in females (OR per 1-SD increment: 1.46; 95% CI: 1.08–1.96) than in males and confined to individuals not using antihypertensive medications. The ORs per 1-SD increment were 1.01 (95% CI: 0.68–1.50) among individuals using antihypertensive medications and 1.43 (95% CI: 1.12–1.81) among individuals not using antihypertensive medications. Conclusion: Higher serum UA was positively associated with the prevalence of endothelial dysfunction in samples of the general Japanese population and that positive association was confined to individuals not using antihypertensive medications.
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DOI：
10.1136/heartjnl-2013-304739
发表时间：
2013-12
期刊：
Heart (British Cardiac Society)
影响因子：
--
作者：
Maruhashi T;Soga J;Fujimura N;Idei N;Mikami S;Iwamoto Y;Kajikawa M;Matsumoto T;Hidaka T;Kihara Y;Chayama K;Noma K;Nakashima A;Goto C;Tomiyama H;Takase B;Yamashina A;Higashi Y
通讯作者：
Higashi Y
影响因子：
4.2
作者：
Kanbay, Mehmet;Yilmaz, Mahmut Ilker;Johnson, Richard J.
通讯作者：
Johnson, Richard J.
DOI：
10.1136/bmj.d8190
发表时间：
2012-01-12
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Choi HK;Soriano LC;Zhang Y;Rodríguez LA
通讯作者：
Rodríguez LA
影响因子：
4.8
作者：
Ko, Jiyeon;Kang, Hyun-Jung;Kang, Duk-Hee
通讯作者：
Kang, Duk-Hee
影响因子：
2.8
作者：
Kato, M;Hisatome, I;Somers, VK
通讯作者：
Somers, VK