Shaping vulnerable bodies at the thin boundary between environment and organism : skin, DNA repair, and a genealogy of DNA care strategies

Shaping vulnerable bodies at the thin boundary between environment and organism : skin, DNA repair, and a genealogy of DNA care strategies
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在环境和有机体之间的薄弱边界上塑造脆弱的身体:皮肤、DNA 修复和 DNA 护理策略谱系

DOI:
10.1017/s0269889715000162
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发表时间:
2015
期刊:
影响因子:
0.3
通讯作者:
Alexander v. Schwerin
Alexander v. Schwerin
中科院分区:
人文科学4区
文献类型:
--
作者:
Alexander v. Schwerin

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本文将风险的历史和DNA修复的历史结合在一起,DNA修复是20世纪60年代作为介于分子生物学、遗传学和辐射研究之间的一个研究领域出现的生物现象。着色性干皮病(XP)是一种遗传性的紫外线过敏症,因此对皮肤癌的倾向将成为争论的起点,在20世纪70年代和80年代,DNA修复开始纠缠于创建处于危险中的人体的新模型-在这里概念上被称为身体历史的脆弱性方面-以及与抗突变和抗癌新的蓬勃发展的研究领域相关的预防癌症和增强身体的新尝试。其目的是证明DNA修复在疾病预防方面创造了特殊的尝试:分子增强,寻求寻找在分子水平上增加身体自我修复能力的方法。从这个意义上说,预防意味着增强身体应对已经有毒的世界的环境危害的能力。这一策略最近被美容行业采用,将DNA护理作为皮肤护理研究和抗衰老配方的新目标。
This paper brings together the history of risk and the history of DNA repair, a biological phenomenon that emerged as a research field in between molecular biology, genetics, and radiation research in the 1960s. The case of xeroderma pigmentosum (XP), an inherited hypersensitivity to UV light and, hence, a disposition to skin cancer will be the starting point to argue that, in the 1970s and 1980s, DNA repair became entangled in the creation of new models of the human body at risk – what is here conceptually referred to as the vulnerability aspect of body history – and new attempts at cancer prevention and enhancement of the body associated with the new flourishing research areas of antimutagenesis and anticarcinogenesis. The aim will be to demonstrate that DNA repair created special attempts at disease prevention: molecular enhancement, seeking to identify means to increase the self-repair abilities of the body at the molecular level. Prevention in this sense meant enhancing the body's ability to cope with the environmental hazards of an already toxic world. This strategy has recently been adopted by the beauty industry, which introduced DNA care as a new target for skin care research and anti-aging formulas.
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