Immunohistochemical evidence for a neurotensin striatonigral pathway in the rat brain.
Immunohistochemical evidence for a neurotensin striatonigral pathway in the rat brain.
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大鼠大脑中神经降压素纹状体黑质通路的免疫组织化学证据。
DOI：
10.1016/0306-4522(93)90445-l
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发表时间：
1993
期刊：
影响因子：
3.3
通讯作者：
Hökfelt,T
中科院分区：
文献类型：
--
作者：
Castel,MN;Morino,P;Frey,P;Terenius,L;Hökfelt,T
应用免疫组织化学方法，结合不同药物处理和损毁技术，对大鼠黑质网状部神经降压素样免疫反应纤维的分布和起源进行了研究，发现正常大鼠黑质网状部中央部有一个明显但弱荧光的神经降压素样免疫反应纤维网络。当动物用利血平治疗时，它抑制多巴胺的传递，发现了类似的免疫反应模式，尽管染色强度略有增强。然而，当老鼠接受甲基苯丙胺（一种有效的多巴胺释放剂）治疗时，免疫反应的强度急剧增加。特别是，密集包装的神经紧张素免疫反应纤维被发现在背侧边界和腹侧周边的黑质网状部。发现这种免疫反应性模式与强啡肽所显示的相似。在尾状核，几个神经降压素免疫反应阳性细胞体后利血平处理。形态学上相似的perikarya观察甲基苯丙胺治疗的大鼠，但他们是为数不多的，而没有细胞体在未处理的动物中检测。当单侧机械横断或鹅膏蕈氨酸注射在纹状体，神经降压素以及强啡肽和P物质的免疫反应性在黑质网状部的模式受到强烈影响。这两种类型的病变引起了显着的，平行耗尽的所有三种免疫反应性物质的同侧病变，其中一个限制区域几乎没有免疫反应性元素。因此，本研究提供了证据，存在一个单侧的神经降压素纹状体黑质通路，终止于网状部。起源的神经降压素纤维在pars rectaga.These结果与证据一起从文献中表明，甲基苯丙胺诱导大量释放多巴胺从黑质树突作用于突触前D1多巴胺受体位于neurotensinergic终端导致一个显着增加neurotensin-like免疫反应性在pars reticulata的起源尚未建立，但似乎不是尾状核。
The distribution and origin of neurotensin-like immunoreactivity in the substantia nigra pars reticulata of the rat have been analysed using immunohistochemistry combined with different drug treatments and lesioning techniques.In normal rats, a distinct but weakly fluorescent network of neurotensin-immunoreactive fibers was found in the central part of the substantia nigra pars reticulata. When the animals were treated with reserpine, which suppresses dopamine transmission, a similar pattern of immunoreactivity was found, though the intensity of staining was slightly enhanced. However, when rats were treated with methamphetamine, a potent dopamine releaser, the intensity of immunoreactivity was dramatically increased. In particular, densely packed neurotensin-immunoreactive fibers were found at the dorsal border and at the ventral periphery of the substantia nigra pars reticulata. This pattern of immunoreactivity was found to be similar to that displayed by dynorphin. In the nucleus caudatus, several neurotensin-immunoreactive cell bodies were seen after reserpine treatment. Morphologically similar perikarya were observed in methamphetamine-treated rats, but they were less numerous, whereas no cell bodies were detectable in untreated animals. When a unilateral mechanical transection or an ibotenic acid injection was performed in the striatum, the patterns of neurotensin as well as dynorphin and substance P immunoreactivities in the substantia nigra pars reticulata were strongly affected. Both types of lesion caused a marked, parallel depletion of all three immunoreactive substances on the side ipsilateral to the lesion, where a restricted area was virtually devoid of immunoreactive elements. Thus the present study provides evidence for the existence of a unilateral neurotensin striatonigral pathway, terminating in the pars reticulata. The origin of the neurotensin fibers in the pars compacta has not been established but does not appear to be the caudate nucleus.These results together with evidence from the literature suggest that methamphetamine induced a massive release of dopamine from nigral dendrites acting on presynaptic D1dopamine receptors located on neurotensinergic terminals leading to a marked increase in neurotensin-like immunoreactivity in the pars reticulata.
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DOI：
10.1073/pnas.82.24.8629
发表时间：
1985-12-01
影响因子：
11.1
作者：
PODACK, ER;YOUNG, JDE;COHN, ZA
通讯作者：
COHN, ZA
溶组织内阿米巴细胞毒素：纯化、表征、菌株毒力和蛋白酶活性。
影响因子：
6.4
作者：
K. McGowan;C. Deneke;G. Thorne;S. Gorbach
通讯作者：
S. Gorbach
DOI：
--
发表时间：
1967
期刊：
影响因子：
--
作者：
G. Schatz;H. Penefsky;E. Racker
通讯作者：
E. Racker
溶组织内阿米巴产生透明质酸酶的研究
DOI：
--
发表时间：
1953
期刊：
影响因子：
--
作者：
J. Bradin
通讯作者：
J. Bradin
弱酸性蛋白酶在溶组织内阿米巴中具有强大的蛋白水解活性。
DOI：
--
发表时间：
1984
期刊：
Molecular and biochemical parasitology (Print)
影响因子：
--
作者：
H. Scholze;E. Werries
通讯作者：
E. Werries