Study of the anticancer effects of a helium plasma jet combined with four anticancer drugs on 3D bladder tumour spheroids
Study of the anticancer effects of a helium plasma jet combined with four anticancer drugs on 3D bladder tumour spheroids
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氦等离子体射流联合四种抗癌药物对3D膀胱肿瘤球体的抗癌作用研究
DOI：
10.1002/ppap.202000226
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发表时间：
2021-02
影响因子：
3.5
通讯作者：
Kong Michael G.
中科院分区：
文献类型：
--
作者：
Zhang Jishen;Li Bing;Xu Shengduo;Liu Dingxin;Zhang Hao;Xu Dehui;Guo Li;Kong Michael G.
目前冷等离子体治疗肿瘤的研究主要集中在单独应用等离子体，而忽视了等离子体与传统治疗技术的联合应用。本文研究了等离子体射流联合四种临床抗癌药物（顺铂、甲氨蝶呤、阿霉素和紫杉醇）对三维膀胱肿瘤球体（T24细胞）的抗癌作用。结果表明，4种药物对等离子体射流诱导的液相氧化压影响不大，抗癌作用由强到弱依次为：等离子体射流+紫杉醇、等离子体射流+阿霉素、等离子体射流+顺铂、等离子体射流和等离子体射流+甲氨蝶呤。我们的研究表明，血浆在与特定抗癌药物组合时表现出选择性。
Current studies of cold atmospheric plasma cancer therapy mainly focus on the application of plasma alone and neglect the application of plasma combined with traditional therapeutic techniques. In this paper, the anticancer effects of a plasma jet combined with four clinical anticancer drugs (cisplatin, methotrexate, adriamycin and paclitaxel) on three‐dimensional bladder tumour spheroids (T24 cells) were studied. The results show that all four drugs had little impact on the liquid‐phase oxidative pressure induced by the plasma jet, and anticancer effects from strong to weak were as follows: Plasma jet + paclitaxel, plasma jet + adriamycin, plasma jet + cisplatin, plasma jet and plasma jet + methotrexate. Our research indicates that plasma exhibits selectivity in combination with particular anticancer drugs.
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