What we are learning on HTLV-1 pathogenesis from animal models.
What we are learning on HTLV-1 pathogenesis from animal models.
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DOI：
10.3389/fmicb.2012.00320
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发表时间：
2012
影响因子：
5.2
通讯作者：
Lairmore M
中科院分区：
文献类型：
--
作者：
Dodon MD;Villaudy J;Gazzolo L;Haines R;Lairmore M
人类 T 细胞白血病病毒 1 型 (HTLV-1) 于 30 多年前被分离和鉴定，是成人 T 细胞白血病/淋巴瘤的病原体，这是一种活化的 CD4+ T 细胞的侵袭性淋巴增殖性疾病，以及其他炎症性疾病，例如 HTLV-1 相关的脊髓病/热带痉挛性截瘫。各种动物模型为了解 HTLV-1 传播、发病机制以及治疗 HTLV-1 相关疾病的新疗法的设计做出了贡献。小动物模型（兔子、大鼠和小鼠）以及大型动物模型（猴子）已被用来显着推进病毒蛋白和病毒感染细胞在感染早期阶段以及白血病和免疫致病过程发展中的表征。在过去的二十年里，新的免疫功能低下小鼠品系的诞生，在移植人体组织或祖细胞后，能够通过功能性人类免疫系统（HIS）进行稳健重建，彻底改变了病毒感染和发病机制的体内研究。最近在发生淋巴瘤的 HTLV-1 感染人源化 HIS 小鼠中获得的观察结果为研究不同淋巴器官中人类 T 细胞中前病毒克隆的进化提供了机会。目前在改进这些人源化模型方面取得的进展将有利于药物测试和针对 HTLV-1 相关疾病的靶向疗法的开发。
Isolated and identified more than 30 years ago, human T cell leukemia virus type 1 (HTLV-1) is the etiological agent of adult T cell leukemia/lymphoma, an aggressive lymphoproliferative disease of activated CD4+ T cells, and other inflammatory disorders such as HTLV-1-associated myelopathy/tropical spastic paraparesis. A variety of animal models have contributed to the fundamental knowledge of HTLV-1 transmission, pathogenesis, and to the design of novel therapies to treat HTLV-1-associated diseases. Small animal models (rabbits, rats, and mice) as well as large animal models (monkeys) have been utilized to significantly advance characterization of the viral proteins and of virus-infected cells in the early steps of infection, as well as in the development of leukemogenic and immunopathogenic processes. Over the past two decades, the creation of new immunocompromised mouse strains that are robustly reconstituted with a functional human immune system (HIS) after being transplanted with human tissues or progenitor cells has revolutionized the in vivo investigation of viral infection and pathogenesis. Recent observations obtained in HTLV-1-infected humanized HIS mice that develop lymphomas provide the opportunity to study the evolution of the proviral clonality in human T cells present in different lymphoid organs. Current progress in the improvement of those humanized models will favor the testing of drugs and the development of targeted therapies against HTLV-1-associated diseases.
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影响因子：
3.3
作者：
Banerjee P;Crawford L;Samuelson E;Feuer G
通讯作者：
Feuer G
DOI：
10.1073/pnas.92.4.1057
发表时间：
1995-02-14
影响因子：
11.1
作者：
GROSSMAN, WJ;KIMATA, JT;RATNER, L
通讯作者：
RATNER, L
影响因子：
5.4
作者：
Brainard, Diana M.;Seung, Edward;Tager, Andrew M.
通讯作者：
Tager, Andrew M.
影响因子：
5.4
作者：
Hasegawa, A;Ohashi, T;Kannagi, M
通讯作者：
Kannagi, M
影响因子：
5.4
作者：
Hakata, Y;Yamada, M;Shida, H
通讯作者：
Shida, H