Chronic traumatic encephalopathy: a potential late effect of sport-related concussive and subconcussive head trauma.
Chronic traumatic encephalopathy: a potential late effect of sport-related concussive and subconcussive head trauma.
复制标题
DOI：
10.1016/j.csm.2010.09.007
复制
发表时间：
2011-01
影响因子：
2
通讯作者：
McKee, Ann C.
中科院分区：
文献类型：
--
作者：
Gavett, Brandon E.;Stern, Robert A.;McKee, Ann C.
关键词：
慢性创伤性脑病（CTE）是一种神经退行性疾病，被认为是由反复的头部损伤引起的。最初被称为拳击员痴呆症，因为它与拳击有关，CTE的神经病理学于1973年由Corsellis在15名退役拳击手的病例系列中首次描述。CTE最近被发现发生在重复头部创伤的其他原因之后，这表明任何对头部的重复打击，例如由于美式足球，曲棍球，足球，职业摔跤和身体虐待而发生的打击，也可能导致神经退行性变化。这些变化通常包括脑萎缩、透明隔腔开窗、乳头体收缩、致密tau免疫反应性包涵体（神经元缠结、神经胶质缠结和神经轴突突起）、弥漫性轴索损伤，以及在某些情况下的TDP-43蛋白病。与这些病理变化相关，受影响的个体通常表现出记忆和执行功能障碍、行为和人格障碍（例如，冷漠、抑郁、易怒、冲动、自杀倾向）、帕金森综合征，以及偶尔的运动神经元疾病。目前，CTE还没有正式的临床或病理诊断标准，但这种疾病独特的神经病理学特征为未来的预防，诊断和治疗研究提供了希望。
Chronic traumatic encephalopathy (CTE) is a form of neurodegeneration that is believed to result from repeated head injuries. Originally termed dementia pugilistica due to its association with boxing, the neuropathology of CTE was first described by Corsellis in 1973 in a case series of 15 retired boxers. CTE has recently been found to occur following other causes of repeated head trauma, suggesting that any repeated blows to the head, such as those that occur due to American football, hockey, soccer, professional wrestling, and physical abuse, can also lead to neurodegenerative changes. These changes often include cerebral atrophy, cavum septum pellucidum with fenestrations, shrinkage of the mammillary bodies, dense tau immunoreactive inclusions (neurofibrillary tangles, glial tangles, and neuropil neurites), diffuse axonal injury, and, in some cases, a TDP-43 proteinopathy. In association with these pathological changes, affected individuals often exhibit disordered memory and executive functioning, behavioral and personality disturbances (e.g., apathy, depression, irritability, impulsiveness, suicidality), parkinsonism, and, occasionally, motor neuron disease. At the present time, there are no formal clinical or pathological diagnostic criteria for CTE, but the distinctive neuropathological profile of the disorder lends promise for future research into its prevention, diagnosis, and treatment.
登录
查看更多内容
影响因子：
105.7
作者：
CRITCHLEY, M
通讯作者：
CRITCHLEY, M
DOI：
10.1073/pnas.94.9.4733
发表时间：
1997-04-29
影响因子：
11.1
作者：
Hall, GF;Yao, J;Lee, G
通讯作者：
Lee, G
DOI：
10.1001/jama.1928.02700150029009
发表时间：
1928-07-01
影响因子：
--
作者：
Martland, HS
通讯作者：
Martland, HS
影响因子：
2.5
作者：
GENTLEMAN, SM;NASH, MJ;ROBERTS, GW
通讯作者：
ROBERTS, GW
影响因子：
4.8
作者：
Frost, Bess;Jacks, Rachel L.;Diamond, Marc I.
通讯作者：
Diamond, Marc I.