Thalamic dual control of sleep and wakefulness.
Thalamic dual control of sleep and wakefulness.
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DOI：
10.1038/s41593-018-0164-7
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发表时间：
2018-07
影响因子：
25
通讯作者：
Adamantidis AR
中科院分区：
文献类型：
--
作者：
Gent TC;Bandarabadi M;Herrera CG;Adamantidis AR
慢波（0.5 - 4 Hz）在哺乳动物非快速眼动（NREM）睡眠期间的皮层脑电图中占主导地位。它们反映了在活跃（UP）和静止（Down）状态之间交替并沿沿着新皮层传播的大型神经元集合的同步。丘脑对皮质UP状态和睡眠调节的作用尚不清楚。在这里，我们表明，自发放电的中央丘脑（CMT）神经元在小鼠的相位先进的全球皮质UP状态和NREM觉醒过渡。CMT神经元的紧张性光遗传激活诱导NREM-觉醒转换，而爆发激活模拟扣带皮层（CING）中的UP状态，并通过前背丘脑（AD）中的中继增强睡眠期间皮层慢波的全脑同步。最后，我们证明CMT和AD中继神经元促进睡眠恢复。这些发现表明，CMT神经元的放电模式可以调节睡眠期间全脑皮层活动，并提供睡眠-觉醒状态的双重控制。
Slow-waves (0.5 - 4 Hz) predominate in the cortical electroencephalogram during non-rapid eye movement (NREM) sleep in mammals. They reflect the synchronization of large neuronal ensembles alternating between active (UP) and quiescent (Down) states and propagating along the neocortex. The thalamic contribution to cortical UP-states and sleep modulation remains unclear. Here we show that spontaneous firing of centromedial thalamus (CMT) neurons in mice is phase advanced to global cortical UP-states and NREM–wake transitions. Tonic optogenetic activation of CMT neurons induces NREM–wake transitions, whereas burst activation mimics UP-states in the cingulate cortex (CING) and enhances brain-wide synchrony of cortical slow-waves during sleep, through a relay in the antero-dorsal thalamus (AD). Finally, we demonstrate that CMT and AD relay neurons promote sleep recovery. These findings suggest that the firing pattern of CMT neurons can modulate brain-wide cortical activity during sleep and provides dual control of sleep-wake states.
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影响因子：
25
作者：
Giber K;Diana MA;Plattner V;Dugué GP;Bokor H;Rousseau CV;Maglóczky Z;Havas L;Hangya B;Wildner H;Zeilhofer HU;Dieudonné S;Acsády L
通讯作者：
Acsády L
影响因子：
16.6
作者：
Anaclet C;Pedersen NP;Ferrari LL;Venner A;Bass CE;Arrigoni E;Fuller PM
通讯作者：
Fuller PM
影响因子：
7.7
作者：
Liu J;Lee HJ;Weitz AJ;Fang Z;Lin P;Choy M;Fisher R;Pinskiy V;Tolpygo A;Mitra P;Schiff N;Lee JH
通讯作者：
Lee JH
影响因子：
5.3
作者：
David, Franois;Schmiedt, Joscha T.;Crunelli, Vincenzo
通讯作者：
Crunelli, Vincenzo
影响因子：
5.3
作者：
Lemieux, Maxime;Chen, Jen-Yung;Timofeev, Igor
通讯作者：
Timofeev, Igor