Intracranial plaque enhancement in patients with cerebrovascular events on high-spatial-resolution MR images.
Intracranial plaque enhancement in patients with cerebrovascular events on high-spatial-resolution MR images.
复制标题
高间隙 - 分辨率MR图像上脑血管事件患者的颅内斑块增强。
DOI：
10.1148/radiol.13122812
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发表时间：
2014-05
期刊：
影响因子：
19.7
通讯作者：
Wasserman BA
中科院分区：
文献类型：
--
作者：
Qiao Y;Zeiler SR;Mirbagheri S;Leigh R;Urrutia V;Wityk R;Wasserman BA
To characterize intracranial plaque inflammation in vivo by using three-dimensional (3D) high-spatial-resolution contrast material–enhanced black-blood (BB) magnetic resonance (MR) imaging and to investigate the relationship between intracranial plaque inflammation and cerebrovascular ischemic events. The study was approved by the institutional review board and was HIPAA compliant. Twenty-seven patients (19 men; mean age, 56.8 years ± 12.4 [standard deviation]) with cerebrovascular ischemic events (acute stroke, n = 20; subacute stroke, n = 2; chronic stroke, n = 3; transient ischemic attack, n = 2) underwent 3D time-of-flight MR angiography and contrast-enhanced BB 3-T MR imaging for intracranial atherosclerotic disease. Each identified plaque was classified as either culprit (the only or most stenotic lesion upstream from a stroke), probably culprit (not the most stenotic lesion upstream from a stroke), or nonculprit (not within the vascular territory of a stroke). Plaque contrast enhancement was categorized on BB MR images (grade 0, enhancement less than or equal to that of normal arterial walls seen elsewhere; grade 1, enhancement greater than grade 0 but less than that of the pituitary infundibulum; grade 2, enhancement greater than or equal to that of the pituitary infundibulum), and degree of contrast enhancement was calculated. Associations of the likelihood of being a culprit lesion with both plaque contrast-enhancement and plaque thickness were estimated with ordinal logistic regression. Seventy-eight plaques were identified in 20 patients with acute stroke (21 [27%] culprit, 12 [15%] probably culprit, and 45 [58%] nonculprit plaques). In these patients, grade 2 contrast enhancement was associated with culprit plaques (odds ratio 34.6; 95% confidence interval: 4.5, 266.5 compared with grade 0) when adjusted for plaque thickness. Grade 0 was observed in only nonculprit plaques. Culprit plaques had a higher degree of contrast enhancement than did nonculprit plaques (25.9% ± 13.4 vs 13.6% ± 12.3, P = .003). Contrast enhancement of intracranial atherosclerotic plaque is associated with its likelihood to have caused a recent ischemic event and may serve as a marker of its stability, thereby providing important insight into stroke risk.
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影响因子：
3.3
作者：
Busse, Reed F.;Brau, Anja C. S.;Vu, Anthony;Michelich, Charles R.;Bayram, Ersin;Kijowski, Richard;Reeder, Scott B.;Rowley, Howard A.
通讯作者：
Rowley, Howard A.
影响因子：
8.3
作者：
Nahab, Fadi;Cotsonis, George;Chimowitz, Marc
通讯作者：
Chimowitz, Marc
影响因子：
14
作者：
Ibrahim, Tareq;Makowski, Markus R.;Botnar, Rene M.
通讯作者：
Botnar, Rene M.
影响因子：
4.4
作者：
Labadzhyan, Artak;Csiba, Laszlo;Narula, Navneet;Zhou, Jun;Narula, Jagat;Fisher, Mark
通讯作者：
Fisher, Mark
影响因子：
8.3
作者：
Mazighi, Mikael;Labreuche, Julien;Amarenco, Pierre
通讯作者：
Amarenco, Pierre