Seasonal spring peaks of suicide in victims with and without prior history of hospitalization for mood disorders.
Seasonal spring peaks of suicide in victims with and without prior history of hospitalization for mood disorders.
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DOI：
10.1016/j.jad.2009.05.015
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发表时间：
2010-02
影响因子：
6.6
通讯作者：
Qin, Ping
中科院分区：
文献类型：
--
作者：
Postolache, Teodor T.;Mortensen, Preben B.;Tonelli, Leonardo H.;Jiao, Xiaolong;Frangakis, Constantin;Soriano, Joseph J.;Qin, Ping
季节性春季自杀高峰是高度重复的，但其起源却知之甚少。由于春季自杀高峰可能是春季情绪障碍失代偿的结果，我们假设先前的情绪障碍史与春季自杀具有预测性。方法对1970年至2001年丹麦死亡原因登记处的37,987例自杀病例进行月度自杀率分析。从丹麦精神病学中央登记处获得情绪障碍史，从劳动力市场研究综合数据库获得社会经济数据。每月自杀率比相对于12月用泊松回归估计。采用条件logistic回归分析比较了因情绪障碍住院与未住院的个体自杀的季节性，并对收入、婚姻状况、居住地和自杀方式进行了调整。结果两组患者春季自杀高峰均有统计学意义。有情绪障碍病史与春季自杀风险增加相关（男性：RR=1.18, 95% CI 1.07-1.31；女性：RR=1.20, 95% CI 1.10-1.32）。局限性：未分析II轴疾病的病史。丹麦的社会经济现实只有有限的普遍性。结论该结果支持进一步调查春季情绪障碍加重是否引发季节性自杀高峰的必要性。确定季节性春季自杀高峰的触发因素可能会导致发现新的危险因素和自杀预防的治疗靶点。
BACKGROUNDSeasonal spring peaks of suicide are highly replicated, but their origin is poorly understood. As the peak of suicide in spring could be a consequence of decompensation of mood disorders in spring, we hypothesized that prior history of mood disorders is predictively associated with suicide in spring.METHODSWe analyzed the monthly rates of suicide based upon all 37,987 suicide cases in the Danish Cause of Death Registry from 1970 to 2001. History of mood disorder was obtained from the Danish Psychiatric Central Register and socioeconomical data from the Integrated Database for Labour Market Research. The monthly rate ratio of suicide relative to December was estimated using a Poisson regression. Seasonality of suicide between individuals with versus without hospitalization for mood disorders was compared using conditional logistic regression analyses with adjustment for income, marital status, place of residence, and method of suicide.RESULTSA statistically significant spring peak in suicide was observed in both groups. A history of mood disorders was associated with an increased risk of suicide in spring (for males: RR=1.18, 95% CI 1.07–1.31; for females: RR=1.20, 95% CI 1.10–1.32).LIMITATIONSHistory of axis II disorders was not analyzed. Danish socioeconomical realities have only limited generalizability.CONCLUSIONSThe results support the need to further investigate if exacerbation of mood disorders in spring triggers seasonal peaks of suicide. Identifying triggers for seasonal spring peaks in suicide may lead to uncovering novel risk factors and therapeutic targets for suicide prevention.
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