Effects of Active Components of Fuzi and Gancao Compatibility on Bax, Bcl-2, and Caspase-3 in Chronic Heart Failure Rats.
Effects of Active Components of Fuzi and Gancao Compatibility on Bax, Bcl-2, and Caspase-3 in Chronic Heart Failure Rats.
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附子与甘草配伍活性成分对慢性心力衰竭大鼠Bax、Bcl-2、Caspase-3的影响
DOI：
10.1155/2016/7686045
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Wan H
中科院分区：
文献类型：
--
作者：
Wang L;He Y;Zhang Y;Zhou H;Yu L;Yang J;Wan H
次乌头碱（HA）和甘草次酸（GA）是附子和甘草的活性成分，自古以来就被用于慢性心力衰竭（CHF）的配伍。本研究旨在探讨细胞凋亡途径是否与HA + GA对CHF大鼠的保护作用有关。采用腹主动脉缩窄术（TAC）建立CHF模型4周后，分别给予地高辛（1 mg/kg）、透明质酸（2.07mg/kg）、赤霉素（25 mg/kg）、透明质酸（2.07mg/kg）+赤霉素（25 mg/kg）灌胃1周。HA + GA组血浆BNP和cTnI水平降低，心脏/体重比（H/B）和经胸超声心动图左室参数降低，免疫组化和western blot法显示HA + GA组Bax、Bcl-2和caspase-3的表达均较其他组增强。结论：附子甘草配伍对CHF大鼠心肌细胞凋亡具有保护作用，为进一步探讨其作用机制提供了有力证据。
Hypaconitine (HA) and glycyrrhetinic acid (GA) are active components of Fuzi (Aconitum carmichaelii) and Gancao (Glycyrrhiza uralensis Fisch); they have been used in compatibility for chronic heart failure (CHF) from ancient times. The purpose of the present research was to explore whether apoptosis pathways were related with the protective effects of HA + GA against CHF rats or not. The rats were progressed with transverse-aortic constriction (TAC) operation for 4 weeks to build the CHF state, and then the Digoxin (1 mg/kg), HA (2.07 mg/kg), GA (25 mg/kg), and HA (2.07 mg/kg) + GA (25 mg/kg) were orally administrated to rats for 1 week. The levels of BNP and cTnI in the plasma were decreased in the HA + GA group, and the heart/body weight ratio (H/B) and left ventricular (LV) parameters of transthoracic echocardiography were also declined; moreover, the expressions of Bax, Bcl-2, and caspase-3 were all improved in the HA + GA group than other groups in the immunohistochemistry and western blot methods. In general, the data suggested that Fuzi and Gancao compatibility could protect the CHF rats from apoptosis, which provided a strong evidence for further searching for mechanisms of them.
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