8q24 sequence variants in relation to prostate cancer risk among men of African descent: a case-control study.
8q24 sequence variants in relation to prostate cancer risk among men of African descent: a case-control study.
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DOI：
10.1186/1471-2407-10-334
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发表时间：
2010-06-28
期刊：
影响因子：
3.8
通讯作者：
Kidd LR
中科院分区：
文献类型：
--
作者：
Benford ML;VanCleave TT;Lavender NA;Kittles RA;Kidd LR
人类染色体8q24与前列腺肿瘤发生有关。因此，我们评估了7个8q24序列变异相对于前列腺癌（PCA）的病例对照研究，涉及非洲裔男性。采用TaqMan聚合酶链反应（PCR）检测了195例PCA病例和531例对照的生殖系DNA中的遗传变异。对于我们的测试组，8q24 rs16901979 T等位基因的遗传对应于发生PCA的风险增加2.5倍。使用多因素降维（MDR）和排列检验（p = 0.038）验证了这些结果。其余8q24靶点与PCA结果无显著相关。虽然令人信服的证据表明，8q24 rs16901979位点可以作为一个有效的PCA预测，我们的研究结果需要在更大的研究进行额外的评估。
Human chromosome 8q24 has been implicated in prostate tumorigenesis. Consequently, we evaluated seven 8q24 sequence variants relative to prostate cancer (PCA) in a case-control study involving men of African descent. Genetic alterations were detected in germ-line DNA from 195 incident PCA cases and 531 controls using TaqMan polymerase chain reaction (PCR). Inheritance of the 8q24 rs16901979 T allele corresponded to a 2.5-fold increase in the risk of developing PCA for our test group. These findings were validated using multifactor dimensionality reduction (MDR) and permutation testing (p = 0.038). The remaining 8q24 targets were not significantly related to PCA outcomes. Although compelling evidence suggests that the 8q24 rs16901979 locus may serve as an effective PCA predictor, our findings require additional evaluation in larger studies.
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DOI：
10.1158/1055-9965.epi-08-0523
发表时间：
2008-11
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Park SL;Chang SC;Cai L;Cordon-Cardo C;Ding BG;Greenland S;Hussain SK;Jiang Q;Liu S;Lu ML;Mao JT;Morgenstern H;Mu LN;Ng LJ;Pantuck A;Rao J;Reuter VE;Tashkin DP;You NC;Yu CQ;Yu SZ;Zhao JK;Belldegrun A;Zhang ZF
通讯作者：
Zhang ZF
影响因子：
5.8
作者：
Hahn, LW;Ritchie, MD;Moore, JH
通讯作者：
Moore, JH
影响因子：
11.2
作者：
Schumacher, Fredrick R.;Feigelson, Heather Spencer;Hunter, David J.
通讯作者：
Hunter, David J.
影响因子：
7
作者：
Robbins, Christiane;Torres, Jada Benn;Carpten, John
通讯作者：
Carpten, John
影响因子：
30.8
作者：
Haiman, Christopher A.;Patterson, Nick;Reich, David
通讯作者：
Reich, David