Immune system to brain signaling: neuropsychopharmacological implications.
Immune system to brain signaling: neuropsychopharmacological implications.
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DOI：
10.1016/j.pharmthera.2011.01.014
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发表时间：
2011-05
影响因子：
13.5
通讯作者：
Miller, Andrew H.
中科院分区：
文献类型：
--
作者：
Capuron, Lucile;Miller, Andrew H.
我们对免疫系统影响大脑和行为的途径和机制的了解有了爆炸性增长。在炎症的情况下，促炎细胞因子能够进入中枢神经系统，并与大脑中的细胞因子网络相互作用，从而几乎影响与行为相关的大脑功能的各个方面，包括神经递质代谢、神经内分泌功能、突触可塑性以及调节情绪、运动活动、动机、焦虑和警觉的神经回路。免疫系统对大脑的这些影响所导致的行为后果包括抑郁、焦虑、疲劳、精神运动迟缓、厌食、认知功能障碍和睡眠障碍；这些症状与神经精神疾病（尤其是抑郁症）的特征症状有重叠。在免疫系统对大脑的影响中，似乎特别重要的途径包括细胞因子信号分子、p38丝裂原活化蛋白激酶和核因子κB；吲哚胺2,3 - 双加氧酶及其下游代谢产物犬尿氨酸、喹啉酸和犬尿酸；神经递质血清素、多巴胺和谷氨酸；以及涉及基底神经节和前扣带回皮质的神经回路。一系列的易患因素，包括衰老、肥胖以及慢性应激，似乎也与免疫 - 大脑信号传导相互作用，加剧了免疫对神经精神疾病的影响。对免疫系统影响行为的机制的阐明为潜在的治疗开发提供了大量靶点，并为高危人群预防神经精神疾病提供了策略依据。
There has been an explosion in our knowledge of the pathways and mechanisms by which the immune system can influence the brain and behavior. In the context of inflammation, pro-inflammatory cytokines can access the central nervous system and interact with a cytokine network in the brain to influence virtually every aspect of brain function relevant to behavior including neurotransmitter metabolism, neuroendocrine function, synaptic plasticity, and neurocircuits that regulate mood, motor activity, motivation, anxiety and alarm. Behavioral consequences of these effects of the immune system on the brain include depression, anxiety, fatigue, psychomotor slowing, anorexia, cognitive dysfunction and sleep impairment; symptoms that overlap with those which characterize neuropsychiatric disorders, especially depression. Pathways that appear to be especially important in immune system effects on the brain include the cytokine signaling molecules, p38 mitogen activated protein kinase and nuclear factor kappa B; indoleamine 2,3 dioxygenase and its down stream metabolites, kynurenine, quinolinic acid and kynurenic acid; the neurotransmitters, serotonin, dopamine and glutamate; and neurocircuits involving the basal ganglia and anterior cingulate cortex. A series of vulnerability factors including aging and obesity as well as chronic stress also appear to interact with immune to brain signaling to exacerbate immunologic contributions to neuropsychiatric disease. The elucidation of the mechanisms by which the immune system influences behavior yields a host of targets for potential therapeutic development as well as informing strategies for the prevention of neuropsychiatric disease in at risk populations.
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影响因子：
30.5
作者：
Acosta-Rodriguez, Eva V.;Napolitani, Giorgio;Sallusto, Federica
通讯作者：
Sallusto, Federica
影响因子：
4.2
作者：
Buntinx, M;Moreels, M;Ameloot, M
通讯作者：
Ameloot, M
影响因子：
25.7
作者：
Cai, W;Khaoustov, VI;Yoffe, B
通讯作者：
Yoffe, B
DOI：
10.1084/jem.20070663
发表时间：
2007-08-06
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Annunziato F;Cosmi L;Santarlasci V;Maggi L;Liotta F;Mazzinghi B;Parente E;Filì L;Ferri S;Frosali F;Giudici F;Romagnani P;Parronchi P;Tonelli F;Maggi E;Romagnani S
通讯作者：
Romagnani S
影响因子：
5.8
作者：
Bastard, JP;Jardel, C;Hainque, B
通讯作者：
Hainque, B