Genome-wide association mapping reveals a rich genetic architecture of complex traits in Oryza sativa.
Genome-wide association mapping reveals a rich genetic architecture of complex traits in Oryza sativa.
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DOI：
10.1038/ncomms1467
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发表时间：
2011-09-13
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
--
作者：
亚洲水稻，Oryza sativa是一种培育的近亲繁殖物种，养活了世界一半以上的人口。了解水稻不同生理、发育和形态性状的遗传基础为提高水稻产量、品质和可持续性提供了基础。在这里，我们展示了一个全基因组关联研究的结果，该研究基于对413个不同的O.从82个国家收集的34个性状的系统表型。使用基于交叉群体的映射策略，我们确定了数十种影响众多复杂性状的常见变异。在与亚群结构和对环境的反应相关的遗传结构中观察到显着的异质性。这项工作为水稻全基因组关联研究建立了一个开源的转化研究平台，将基因和代谢途径中的分子变异与加速品种开发和作物改良所需的种质资源直接联系起来。 了解驯化物种的遗传学和生理学对于作物改良是重要的。通过研究413个不同水稻品种的自然变异和表型性状，Zhao等人确定了许多影响种子大小和开花时间等数量性状的常见遗传变异。
Asian rice, Oryza sativa is a cultivated, inbreeding species that feeds over half of the world's population. Understanding the genetic basis of diverse physiological, developmental, and morphological traits provides the basis for improving yield, quality and sustainability of rice. Here we show the results of a genome-wide association study based on genotyping 44,100 SNP variants across 413 diverse accessions of O. sativa collected from 82 countries that were systematically phenotyped for 34 traits. Using cross-population-based mapping strategies, we identified dozens of common variants influencing numerous complex traits. Significant heterogeneity was observed in the genetic architecture associated with subpopulation structure and response to environment. This work establishes an open-source translational research platform for genome-wide association studies in rice that directly links molecular variation in genes and metabolic pathways with the germplasm resources needed to accelerate varietal development and crop improvement. Understanding the genetics and physiology of domesticated species is important for crop improvement. By studying natural variation and the phenotypic traits of 413 diverse accessions of rice, Zhao et al. identify many common genetic variants that influence quantitative traits such as seed size and flowering time.
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DOI：
10.2183/pjab.86.265
发表时间：
2010
期刊：
Proceedings of the Japan Academy. Series B, Physical and biological sciences
影响因子：
--
作者：
Asano K;Miyao A;Hirochika H;Kitano H;Matsuoka M;Ashikari M
通讯作者：
Ashikari M
影响因子：
2.4
作者：
Ebana, Kaworu;Yonemaru, Jun-ichi;Yano, Masahiro
通讯作者：
Yano, Masahiro
影响因子：
3.1
作者：
Fujino, Kenji;Wu, Jianzhong;Matsumoto, Takashi
通讯作者：
Matsumoto, Takashi
影响因子：
4.5
作者：
Brachi B;Faure N;Horton M;Flahauw E;Vazquez A;Nordborg M;Bergelson J;Cuguen J;Roux F
通讯作者：
Roux F
影响因子：
4.5
作者：
Famoso AN;Zhao K;Clark RT;Tung CW;Wright MH;Bustamante C;Kochian LV;McCouch SR
通讯作者：
McCouch SR