Systemic autoimmunity in TAM triple knockout mice causes inflammatory brain damage and cell death.
Systemic autoimmunity in TAM triple knockout mice causes inflammatory brain damage and cell death.
复制标题
DOI：
10.1371/journal.pone.0064812
复制
发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Lu Q
中科院分区：
文献类型：
--
作者：
Li Q;Lu Q;Lu H;Tian S;Lu Q
The Tyro3, Axl and Mertk (TAM) triply knockout (TKO) mice exhibit systemic autoimmune diseases, with characteristics of increased proinflammatory cytokine production, autoantibody deposition and autoreactive lymphocyte infiltration into a variety of tissues. Here we show that TKO mice produce high level of serum TNF-α and specific autoantibodies deposited onto brain blood vessels. The brain-blood barrier (BBB) in mutant brains exhibited increased permeability for Evans blue and fluorescent-dextran, suggesting a breakdown of the BBB in the mutant brains. Impaired BBB integrity facilitated autoreactive T cells infiltrating into all regions of the mutant brains. Brain autoimmune disorder caused accumulation of the ubiquitin-reactive aggregates in the mutant hippocampus, and early formation of autofluorescent lipofuscins in the neurons throughout the entire brains. Chronic neuroinflammation caused damage of the hippocampal mossy fibers and neuronal apoptotic death. This study shows that chronic systemic inflammation and autoimmune disorders in the TKO mice cause neuronal damage and death.
登录
查看更多内容
影响因子：
2.6
作者：
Abbott, NJ;Mendonça, LLF;Dolman, DEM
通讯作者：
Dolman, DEM
影响因子：
2.9
作者：
Ballok, DA;Millward, JM;Sakic, B
通讯作者：
Sakic, B
影响因子：
3.5
作者：
Ballok, DA;Woulfe, J;Sakic, B
通讯作者：
Sakic, B
影响因子：
5.7
作者：
MacKenzie-Graham, Allan;Tiwari-Woodruff, Seema K.;Voskuhl, Rhonda R.
通讯作者：
Voskuhl, Rhonda R.
影响因子：
11.2
作者：
Holland, SJ;Powell, MJ;Lorens, JB
通讯作者：
Lorens, JB