Disease-Specific Contribution of Pulvinar Dysfunction to Impaired Emotion Recognition in Schizophrenia.
Disease-Specific Contribution of Pulvinar Dysfunction to Impaired Emotion Recognition in Schizophrenia.
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DOI：
10.3389/fnbeh.2021.787383
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发表时间：
2021
影响因子：
3
通讯作者：
Javitt DC
中科院分区：
文献类型：
--
作者：
Martínez A;Tobe RH;Gaspar PA;Malinsky D;Dias EC;Sehatpour P;Lakatos P;Patel GH;Bermudez DH;Silipo G;Javitt DC
管理社交互动的一个重要方面是快速准确地感知和响应面部表情的能力。这种能力高度依赖于早期视觉通路的皮质和皮质下成分的完整处理。社会认知缺陷，包括面部情绪识别（FER）缺陷，是几种神经精神疾病的特征，包括精神分裂症（Sz）和自闭症谱系障碍（ASD）。在这里，我们调查了潜在的视觉感觉的贡献，FER赤字在Sz（n = 28，8/20女性/男性;年龄21-54岁）和成人ASD（n = 20，4/16名女性/男性;年龄19-43岁）与神经型（n = 30，8/22女性/男性;年龄19-54岁）控制使用基于任务的fMRI在隐式静态/动态FER任务。与正常对照组相比，Sz组（d = 1.97）和ASD组（d = 1.13）的FER评分均显著降低，这与上级颞沟（STS）的激活减少相关。在Sz中，STS缺陷通过早期视觉区域（d = 0.85，p = 0.002）和丘脑枕核（d = 0.44，p = 0.042）的激活减少来预测，沿着受损的皮质-枕相互作用。相比之下，ASD参与者显示出早期视觉皮层（d = 1.03，p = 0.001）和枕（d = 0.71，p = 0.015）激活增加的模式。大的效应大小的枕结构和组织学异常先前已被记录在Sz。此外，我们最近已经证明受损枕激活简单的视觉刺激在Sz。在这里，我们提供了第一个证据的疾病特异性贡献受损枕激活的社会认知功能障碍的Sz。
One important aspect for managing social interactions is the ability to perceive and respond to facial expressions rapidly and accurately. This ability is highly dependent upon intact processing within both cortical and subcortical components of the early visual pathways. Social cognitive deficits, including face emotion recognition (FER) deficits, are characteristic of several neuropsychiatric disorders including schizophrenia (Sz) and autism spectrum disorders (ASD). Here, we investigated potential visual sensory contributions to FER deficits in Sz (n = 28, 8/20 female/male; age 21–54 years) and adult ASD (n = 20, 4/16 female/male; age 19–43 years) participants compared to neurotypical (n = 30, 8/22 female/male; age 19–54 years) controls using task-based fMRI during an implicit static/dynamic FER task. Compared to neurotypical controls, both Sz (d = 1.97) and ASD (d = 1.13) participants had significantly lower FER scores which interrelated with diminished activation of the superior temporal sulcus (STS). In Sz, STS deficits were predicted by reduced activation of early visual regions (d = 0.85, p = 0.002) and of the pulvinar nucleus of the thalamus (d = 0.44, p = 0.042), along with impaired cortico-pulvinar interaction. By contrast, ASD participants showed patterns of increased early visual cortical (d = 1.03, p = 0.001) and pulvinar (d = 0.71, p = 0.015) activation. Large effect-size structural and histological abnormalities of pulvinar have previously been documented in Sz. Moreover, we have recently demonstrated impaired pulvinar activation to simple visual stimuli in Sz. Here, we provide the first demonstration of a disease-specific contribution of impaired pulvinar activation to social cognitive impairment in Sz.
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影响因子：
10.6
作者：
Foss-Feig JH;Adkinson BD;Ji JL;Yang G;Srihari VH;McPartland JC;Krystal JH;Murray JD;Anticevic A
通讯作者：
Anticevic A
社会大脑：社会知识的神经基础。
影响因子：
24.8
作者：
Adolphs, Ralph
通讯作者：
Adolphs, Ralph
影响因子：
2.5
作者：
Bishop-Fitzpatrick, Lauren;Mazefsky, Carla A.;Minshew, Nancy J.
通讯作者：
Minshew, Nancy J.
影响因子：
4.5
作者：
Byne, William;Fernandes, Jason;Yiannoulos, Georgia
通讯作者：
Yiannoulos, Georgia
影响因子：
3.7
作者：
Felleman, Daniel J.;Van Essen, David C.
通讯作者：
Van Essen, David C.