Relationship of Time-Activity-Adjusted Particle Number Concentration with Blood Pressure.
Relationship of Time-Activity-Adjusted Particle Number Concentration with Blood Pressure.
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DOI：
10.3390/ijerph15092036
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发表时间：
2018-09-18
影响因子：
--
通讯作者：
Brugge D
中科院分区：
文献类型：
--
作者：
Corlin L;Ball S;Woodin M;Patton AP;Lane K;Durant JL;Brugge D
新出现的证据表明，长期暴露于超细颗粒物（UFP，空气动力学直径< 0.1 µm）与不良心血管结局相关。我们调查了年平均UFP暴露是否与测量的收缩压（SBP），舒张压（DBP），脉压（PP）和高血压患病率在409名成年人参加了横断面社区评估高速公路暴露和健康（CAFEH）研究。我们使用的测量颗粒数浓度（PNC，代理UFP）从移动的监测活动在三个近高速公路和三个城市的背景地区和附近的波士顿，马萨诸塞州开发PNC回归模型（20米的空间和每小时的时间分辨率）。根据在不同微环境中花费的时间调整个体建模估计值（时间-活动调整的PNC，TAA-PNC）。平均TAA-PNC为22，000个微粒/cm 3（sd = 6500）。线性模型中（高血压的逻辑分析）调整有向非循环图（DAG）所示的最低限度的协变量集，我们发现自然对数转换的TAA-PNC和SBP之间存在正相关，但无显著性（β = 5.23，95%CI：−0.68，11.14 mmHg），PP（β = 4.27，95%CI：-0.79，9.32 mmHg）和高血压（OR = 1.81，95%CI：0.94，3.48），但不是DBP（β = 0.96，95%CI：-2.08，4.00 mmHg）。在按种族/民族和健康状况分层的分析中，非西班牙裔白色参与者和糖尿病患者之间的相关性更强。
Emerging evidence suggests long-term exposure to ultrafine particulate matter (UFP, aerodynamic diameter < 0.1 µm) is associated with adverse cardiovascular outcomes. We investigated whether annual average UFP exposure was associated with measured systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), and hypertension prevalence among 409 adults participating in the cross-sectional Community Assessment of Freeway Exposure and Health (CAFEH) study. We used measurements of particle number concentration (PNC, a proxy for UFP) obtained from mobile monitoring campaigns in three near-highway and three urban background areas in and near Boston, Massachusetts to develop PNC regression models (20-m spatial and hourly temporal resolution). Individual modeled estimates were adjusted for time spent in different micro-environments (time-activity-adjusted PNC, TAA-PNC). Mean TAA-PNC was 22,000 particles/cm3 (sd = 6500). In linear models (logistic for hypertension) adjusted for the minimally sufficient set of covariates indicated by a directed acyclic graph (DAG), we found positive, non-significant associations between natural log-transformed TAA-PNC and SBP (β = 5.23, 95%CI: −0.68, 11.14 mmHg), PP (β = 4.27, 95%CI: −0.79, 9.32 mmHg), and hypertension (OR = 1.81, 95%CI: 0.94, 3.48), but not DBP (β = 0.96, 95%CI: −2.08, 4.00 mmHg). Associations were stronger among non-Hispanic white participants and among diabetics in analyses stratified by race/ethnicity and, separately, by health status.
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DOI：
10.1016/s0140-6736(17)30505-6
发表时间：
2017-05-13
期刊：
Lancet (London, England)
影响因子：
--
作者：
Cohen AJ;Brauer M;Burnett R;Anderson HR;Frostad J;Estep K;Balakrishnan K;Brunekreef B;Dandona L;Dandona R;Feigin V;Freedman G;Hubbell B;Jobling A;Kan H;Knibbs L;Liu Y;Martin R;Morawska L;Pope CA 3rd;Shin H;Straif K;Shaddick G;Thomas M;van Dingenen R;van Donkelaar A;Vos T;Murray CJL;Forouzanfar MH
通讯作者：
Forouzanfar MH
影响因子：
11.1
作者：
BONAA, K
通讯作者：
BONAA, K
影响因子：
39.3
作者：
Conen, David;Glynn, Robert J.;Albert, Michelle A.
通讯作者：
Albert, Michelle A.
影响因子：
4.5
作者：
Corlin, Laura;Woodin, Mark;Brugge, Doug
通讯作者：
Brugge, Doug
影响因子：
5.4
作者：
Afable-Munsuz, Aimee;Ponce, Ninez A.;Perez-Stable, Eliseo J.
通讯作者：
Perez-Stable, Eliseo J.