Cellular Mechanisms of Liver Regeneration and Cell-Based Therapies of Liver Diseases.
Cellular Mechanisms of Liver Regeneration and Cell-Based Therapies of Liver Diseases.
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DOI：
10.1155/2017/8910821
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发表时间：
2017
影响因子：
--
通讯作者：
Yarygin KN
中科院分区：
文献类型：
--
作者：
Kholodenko IV;Yarygin KN
再生医学的新兴领域提供了细胞治疗和组织/器官工程的创新方法，作为肝脏疾病治疗的新方法。对肝脏再生的细胞和分子机制的深入研究为肝脏疾病的细胞治疗和肝脏组织器官工程提供了最终的科学基础。损伤诱导的肝再生和体内平衡的细胞机制是独特的。肝实质质量的恢复是通过分化的实质细胞（肝细胞）的代偿性肥大和增生实现的，而驻留的干/祖细胞的扩增和分化起次要或可忽略的作用。已证实骨髓来源的造血细胞参与肝实质再生，但不超过新形成肝细胞的1-2%。肝再生在损伤后自发激活，并且可以通过用肝细胞、造血干细胞或间充质干细胞的细胞疗法进一步刺激。旨在改善肝病细胞治疗结果的进一步研究正在进行中。在肝功能衰竭的情况下，在可预见的将来，工程肝移植可能成为最佳选择。可移植肝脏或其主要部分的工程是一个巨大的挑战，但诱导多能性，组织工程和生物打印研究的快速进展表明它可能是可行的。
The emerging field of regenerative medicine offers innovative methods of cell therapy and tissue/organ engineering as a novel approach to liver disease treatment. The ultimate scientific foundation of both cell therapy of liver diseases and liver tissue and organ engineering is delivered by the in-depth studies of the cellular and molecular mechanisms of liver regeneration. The cellular mechanisms of the homeostatic and injury-induced liver regeneration are unique. Restoration of the mass of liver parenchyma is achieved by compensatory hypertrophy and hyperplasia of the differentiated parenchymal cells, hepatocytes, while expansion and differentiation of the resident stem/progenitor cells play a minor or negligible role. Participation of blood-borne cells of the bone marrow origin in liver parenchyma regeneration has been proven but does not exceed 1-2% of newly formed hepatocytes. Liver regeneration is activated spontaneously after injury and can be further stimulated by cell therapy with hepatocytes, hematopoietic stem cells, or mesenchymal stem cells. Further studies aimed at improving the outcomes of cell therapy of liver diseases are underway. In case of liver failure, transplantation of engineered liver can become the best option in the foreseeable future. Engineering of a transplantable liver or its major part is an enormous challenge, but rapid progress in induced pluripotency, tissue engineering, and bioprinting research shows that it may be doable.
影响因子：
13.5
作者：
Enami, Yuta;Joseph, Brigid;Bandi, Sriram;Lin, Juan;Gupta, Sanjeev
通讯作者：
Gupta, Sanjeev
影响因子：
7.5
作者：
Sasaki K
通讯作者：
Sasaki K