The effects of tea extracts on proinflammatory signaling.
The effects of tea extracts on proinflammatory signaling.
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DOI：
10.1186/1741-7015-4-28
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发表时间：
2006-12-01
期刊：
影响因子：
9.3
通讯作者：
Fiebich B
中科院分区：
文献类型：
--
作者：
Pajonk F;Riedisser A;Henke M;McBride WH;Fiebich B
皮肤毒性是实体瘤放射治疗的常见副作用。它的管理可能会造成治疗空白，从而损害癌症治疗。目前，许多国家没有关于放射治疗期间皮肤治疗的标准建议。在这项研究中，我们探讨了局部应用茶提取物对辐射引起的皮肤毒性持续时间的影响。我们研究了潜在的分子机制，并比较了茶提取物与表没食子儿茶素没食子酸酯（绿茶中最活跃的部分）的作用。回顾性分析了60例头颈癌或盆腔癌患者用绿茶或红茶提取物局部治疗的数据。比较了茶提取物对人单核细胞IL-1β、IL-6、IL-8、TNFα和PGE2释放的调节作用。评价茶提取物对26S蛋白酶体功能的影响。采用emsa法监测NF-κB活性。用MTT法测定巨噬细胞暴露于茶提取物后的活力和辐射反应。茶提取物支持皮肤完整性的恢复。茶提取物抑制蛋白酶体功能，抑制细胞因子释放。与表没食子儿茶素没食子酸酯不同，茶提取物以复杂的半胱天蛋白酶依赖的方式改变NF-κB活性。此外，两种茶提取物，以及表没食子儿茶素没食子酸酯，都能轻微保护巨噬细胞免受电离辐射的影响。茶提取物是一种有效的，广泛适用于急性辐射引起的皮肤毒性患者的治疗选择。有益作用的分子机制是复杂的，而且很可能不完全依赖于茶多酚的作用，如表没食子儿茶素没食子酸酯。
Skin toxicity is a common side effect of radiotherapy for solid tumors. Its management can cause treatment gaps and thus can impair cancer treatment. At present, in many countries no standard recommendation for treatment of skin during radiotherapy exists. In this study, we explored the effect of topically-applied tea extracts on the duration of radiation-induced skin toxicity. We investigated the underlying molecular mechanisms and compared effects of tea extracts with the effects of epigallocatechin-gallate, the proposed most-active moiety of green tea. Data from 60 patients with cancer of the head and neck or pelvic region topically treated with green or black tea extracts were analyzed retrospectively. Tea extracts were compared for their ability to modulate IL-1β, IL-6, IL-8, TNFα and PGE2 release from human monocytes. Effects of tea extracts on 26S proteasome function were assessed. NF-κB activity was monitored by EMSAs. Viability and radiation response of macrophages after exposure to tea extracts was measured by MTT assays. Tea extracts supported the restitution of skin integrity. Tea extracts inhibited proteasome function and suppressed cytokine release. NF-κB activity was altered by tea extracts in a complex, caspase-dependent manner, which differed from the effects of epigallocatechin-gallate. Additionally, both tea extracts, as well as epigallocatechin-gallate, slightly protected macrophages from ionizing radiation Tea extracts are an efficient, broadly available treatment option for patients suffering from acute radiation-induced skin toxicity. The molecular mechanisms underlying the beneficial effects are complex, and most likely not exclusively dependent on effects of tea polyphenols such as epigallocatechin-gallate.
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影响因子：
9.3
作者：
Pajonk F;Riedisser A;Henke M;McBride WH;Fiebich B
通讯作者：
Fiebich B
影响因子：
2
作者：
Taguri, T;Tanaka, T;Kouno, I
通讯作者：
Kouno, I
影响因子：
2.6
作者：
Heggie, S;Bryant, GP;Health, J
通讯作者：
Health, J
影响因子：
4.8
作者：
Potapova, O;Haghighi, A;Mercola, D
通讯作者：
Mercola, D
影响因子：
4.8
作者：
Nam, S;Smith, DM;Dou, QP
通讯作者：
Dou, QP