Resting-state functional connectivity and motor imagery brain activation.

Resting-state functional connectivity and motor imagery brain activation.
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DOI:
10.1002/hbm.23280
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发表时间:
2016-11
影响因子:
4.8
通讯作者:
Inglese, Matilde
Inglese, Matilde
中科院分区:
医学2区
文献类型:
--
作者:
Saiote, Catarina;Tacchino, Andrea;Brichetto, Giampaolo;Roccatagliata, Luca;Bommarito, Giulia;Cordano, Christian;Battaglia, Mario Alberto;Mancardi, Giovanni Luigi;Inglese, Matilde

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运动想象(MI)依赖于对动作的心理模拟,没有任何明显的运动执行(ME),可以促进运动学习并增强神经系统疾病患者的康复效果。虽然 MI 和 ME 期间的功能磁共振成像 (fMRI) 揭示了共享的皮质表征,但参与 MI 的大脑区域的静息态功能连接 (RSFC) 的作用和功能相关性尚不清楚。在这里,我们进行了静息态 fMRI,然后在 ME 和 MI 期间用惯用手进行了 fMRI。我们使用行为计时测试来测量 ME 和 MI 运动持续时间并计算表现指数 (IP)。然后,我们分析了 MI 网络中各个 MI 参数估计和基于种子的 RSFC 图之间的体素匹配相关性,以测量 RSFC 和 MI fMRI 激活之间的对应关系。我们发现 MI 网络中内在连通性的个体间差异预测了多个激活簇。总而言之,目前的研究结果提供了第一个证据,表明 MI 网络内的 RSFC 可以预测 MI 大脑区域的激活,包括与行为表现相关的区域,从而表明 RSFC 在更深入地了解 MI 的神经基质和 MI 能力方面的作用。
Motor imagery (MI) relies on the mental simulation of an action without any overt motor execution (ME), and can facilitate motor learning and enhance the effect of rehabilitation in patients with neurological conditions. While functional magnetic resonance imaging (fMRI) during MI and ME reveals shared cortical representations, the role and functional relevance of the resting-state functional connectivity (RSFC) of brain regions involved in MI is yet unknown. Here, we performed resting-state fMRI followed by fMRI during ME and MI with the dominant hand. We used a behavioral chronometry test to measure ME and MI movement duration and compute an index of performance (IP). Then, we analyzed the voxel-matched correlation between the individual MI parameter estimates and seed-based RSFC maps in the MI network to measure the correspondence between RSFC and MI fMRI activation. We found that inter-individual differences in intrinsic connectivity in the MI network predicted several clusters of activation. Taken together, present findings provide first evidence that RSFC within the MI network is predictive of the activation of MI brain regions, including those associated with behavioral performance, thus suggesting a role for RSFC in obtaining a deeper understanding of neural substrates of MI and of MI ability.
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发表时间: 2008-07-15
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影响因子: 5.7
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影响因子: 5.5
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