Impact of acquisition time and misregistration with CT on data-driven gated PET.
Impact of acquisition time and misregistration with CT on data-driven gated PET.
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DOI：
10.1088/1361-6560/ac5f73
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发表时间：
2022-04-08
影响因子：
3.5
通讯作者：
Pan, Tinsu
中科院分区：
文献类型：
--
作者：
Thomas, M. Allan;Meier, Joseph G.;Mawlawi, Osama R.;Sun, Peng;Pan, Tinsu
数据驱动门控（DDG）可以解决患者运动问题并增强PET量化，但由于PET数据利用率低于100%，图像噪声增加。DDG-PET和CT之间也可能出现错配，从而改变门控的潜在益处。本研究采用DDG-PET/DDG-CT联合技术评估PET采集时间和CT错配的影响。在有感兴趣病变和可能的呼吸运动影响的初级PET床，PET采集时间延长至12分钟，并获得低剂量电影CT以启用DDG-CT。使用30秒至12分钟的PET数据对非门控（NG）和DDG-PET进行回顾性重建。采用标准螺旋CT和DDG-CT对DDG-PET数据进行衰减校正。比较27例肝、肺45个病灶的SUVmax、SUVpeak和CNR。对于NG-PET （p=0.0041）和DDG-PET (p=0.0028)，只有30秒的采集时间相对于3分钟的临床标准表现出明显的SUVmax偏倚。SUVpeak在任何获取时间的变化中都没有表现出偏见。单独DDG-PET可使SUVmax增加15±20% (p<0.0001)， DDG-PET/CT可使SUVmax增加15±29% （p=0.0007）。DDG-PET 3 min和6 min的病灶CNR与NG-PET 3 min相当，但在12 min时增加了28±48% （p=0.0022）。6分钟DDG-PET/CT与3分钟NG-PET计数相当，但CNR显著增加39±46% （p<0.0001）。50%的DDG-PET计数不会导致不准确或有偏差的SUV -增加SUV导致门控。对于增加DDG-PET/CT的SUV， DDG-CT改进配准与DDG-PET运动校正同样重要。当DDG-PET使用与NG-PET相当的计数时，病变检出率可以显著提高，但只有在DDG-PET/CT中与DDG-CT联合使用时，病变检出率才能显著提高。
Data-driven gating (DDG) can address patient motion issues and enhance PET quantification but suffers from increased image noise from utilization of <100% of PET data. Misregistration between DDG-PET and CT may also occur, altering the potential benefits of gating. Here, the effects of PET acquisition time and CT misregistration were assessed with a combined DDG-PET/DDG-CT technique. In the primary PET bed with lesions of interest and likely respiratory motion effects, PET acquisition time was extended to 12 min and a low-dose cine CT was acquired to enable DDG-CT. Retrospective reconstructions were created for both non-gated (NG) and DDG-PET using 30 sec to 12 min of PET data. Both the standard helical CT and DDG-CT were used for attenuation correction of DDG-PET data. SUVmax, SUVpeak, and CNR were compared for 45 lesions in the liver and lung from 27 cases. For both NG-PET (p=0.0041) and DDG-PET (p=0.0028), only the 30 sec acquisition time showed clear SUVmax bias relative to the 3 min clinical standard. SUVpeak showed no bias at any change in acquisition time. DDG-PET alone increased SUVmax by 15±20% (p<0.0001), then was increased further by an additional 15±29% (p=0.0007) with DDG-PET/CT. Both 3 min and 6 min DDG-PET had lesion CNR statistically equivalent to 3 min NG-PET, but then increased at 12 min by 28±48% (p=0.0022). DDG-PET/CT at 6 min had comparable counts to 3 min NG-PET, but significantly increased CNR by 39±46% (p<0.0001). 50% counts DDG-PET did not lead to inaccurate or biased SUV – increased SUV resulted from gating. Improved registration from DDG-CT was equally as important as motion correction with DDG-PET for increasing SUV in DDG-PET/CT. Lesion detectability could be significantly improved when DDG-PET used equivalent counts to NG-PET, but only when combined with DDG-CT in DDG-PET/CT.
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影响因子：
10.6
作者：
Chan C;Onofrey J;Jian Y;Germino M;Papademetris X;Carson RE;Liu C
通讯作者：
Liu C
影响因子：
9.3
作者：
Hamill, James J.;Meier, Joseph G.;Mawlawi, Osama
通讯作者：
Mawlawi, Osama
影响因子：
2.7
作者：
Benjamini, Yoav;Krieger, Abba M.;Yekutieli, Daniel
通讯作者：
Yekutieli, Daniel
影响因子：
3.8
作者：
Kesner, Adam L.;Meier, Joseph G.;Lynch, David A.
通讯作者：
Lynch, David A.
使用最大和峰值标准化摄取值进行 PET 定量时的噪声考虑因素。
DOI：
10.2967/jnumed.111.101733
发表时间：
2012-07
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Lodge MA;Chaudhry MA;Wahl RL
通讯作者：
Wahl RL