Esr1(+) cells in the ventromedial hypothalamus control female aggression.
Esr1(+) cells in the ventromedial hypothalamus control female aggression.
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下丘脑腹内侧的 Esr1( ) 细胞控制女性攻击性
DOI：
10.1038/nn.4644
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发表时间：
2017-11
影响因子：
25
通讯作者：
Lin D
中科院分区：
文献类型：
--
作者：
Hashikawa K;Hashikawa Y;Tremblay R;Zhang J;Feng JE;Sabol A;Piper WT;Lee H;Rudy B;Lin D
攻击作为一种解决冲突的重要手段，两性都会表现出来，但通常男性比女性表现得更强烈。近期研究表明，表达雌激素受体α和孕激素受体（Esr1/PR）的下丘脑腹内侧核腹外侧部分（VMHvl）的细胞对雄性小鼠的攻击行为至关重要，但对雌性小鼠并非如此。相比之下，我们在此表明VMHvl Esr1+细胞在雌性攻击行为中具有不可或缺的作用。当雌性自然发起攻击时，这一细胞群处于活跃状态。使这些细胞失活会减少雌性的攻击行为，而激活它们则会引发攻击。此外，我们发现雌性VMHvl包含两个在解剖学上可区分的亚区，它们在交配和打斗后表现出不同的基因表达、投射和激活模式。这些结果支持了VMHvl在雄性和雌性攻击行为中的重要作用，并揭示了雌性VMHvl中存在两个此前未被重视的亚区，它们参与不同的社会行为。
As an essential means to resolve conflicts, aggression is expressed by both sexes but often at a higher level in males than in females. Recent studies suggest that cells in the ventrolateral part of the ventromedial hypothalamus (VMHvl) that express estrogen receptor alpha and progesterone receptor (Esr1/PR) are essential for male but not female mouse aggression. In contrast, here we show an indispensable role of VMHvlEsr1+ cells in female aggression. This population is active when females attack naturally. Inactivation of these cells reduces female aggression whereas their activation elicits attack. Additionally, we found that female VMHvl contains two anatomically distinguishable subdivisions that show differential gene expression, projection and activation patterns after mating and fighting. These results support an essential role of the VMHvl in both male and female aggression and reveal the existence of two previously unappreciated subdivisions in the female VMHvl that are involved in distinct social behaviors.
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DOI：
10.1073/pnas.0700293104
发表时间：
2007-03-20
影响因子：
11.1
作者：
Armbruster, Blaine N.;Li, Xiang;Roth, Bryan L.
通讯作者：
Roth, Bryan L.
影响因子：
3
作者：
Falkner AL;Lin D
通讯作者：
Lin D
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
64.8
作者：
Cui, Guohong;Jun, Sang Beom;Jin, Xin;Pham, Michael D.;Vogel, Steven S.;Lovinger, David M.;Costa, Rui M.
通讯作者：
Costa, Rui M.
影响因子：
2.5
作者：
Fang, JM;Clemens, LG
通讯作者：
Clemens, LG