Progress towards the prevention and treatment of norovirus infections.
Progress towards the prevention and treatment of norovirus infections.
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DOI：
10.2217/fmb.13.109
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发表时间：
2013-11
影响因子：
3.1
通讯作者：
Goodfellow I
中科院分区：
文献类型：
--
作者：
Arias A;Emmott E;Vashist S;Goodfellow I
诺如病毒现在被认为是发达国家急性胃肠炎的主要原因，但我们预防和控制感染的能力有限。最近的研究强调，虽然在人群中通常是急性感染，但免疫功能低下的患者往往会经历可能持续多年的长期感染。这群患者和那些经常接触传染病材料的人，例如护理人员和其他人，将从疫苗或抗病毒疗法的开发中受益匪浅。虽然尚未开发获得许可的疫苗或抗病毒药物，但过去10年来在这一领域的工作已经加强，候选疫苗的试验被证明是有希望的。现在已经确定了许多在细胞培养中有效的抗病毒靶点和小分子抑制剂；然而，为了使这些药物适合临床使用，还需要在这一领域进行进一步的研究。
Noroviruses are now recognized as the major cause of acute gastroenteritis in the developed world, yet our ability to prevent and control infection is limited. Recent work has highlighted that, while typically an acute infection in the population, immunocompromised patients often experience long-term infections that may last many years. This cohort of patients and those regularly exposed to infectious material, for example, care workers and others, would benefit greatly from the development of a vaccine or antiviral therapy. While a licensed vaccine or antiviral has yet to be developed, work over the past 10 years in this area has intensified and trials with a vaccine candidate have proven promising. Numerous antiviral targets and small molecule inhibitors that have efficacy in cell culture have now been identified; however, further studies in this area are required in order to make these suitable for clinical use.
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DOI：
10.1056/nejmoa1101245
发表时间：
2011-12-08
期刊：
The New England journal of medicine
影响因子：
--
作者：
Atmar RL;Bernstein DI;Harro CD;Al-Ibrahim MS;Chen WH;Ferreira J;Estes MK;Graham DY;Opekun AR;Richardson C;Mendelman PM
通讯作者：
Mendelman PM
影响因子：
5.4
作者：
Changotra, Harish;Jia, Yali;Karst, Stephanie M.
通讯作者：
Karst, Stephanie M.
影响因子：
6.4
作者：
Estes, MK;Ball, JM;Graham, DY
通讯作者：
Graham, DY
影响因子：
4.9
作者：
Carroll, Steven S.;Koeplinger, Kenneth;Erion, Mark D.
通讯作者：
Erion, Mark D.
影响因子：
3.8
作者：
Duizer, E;Schwab, KJ;Estes, MK
通讯作者：
Estes, MK