Scale-up of industrial microbial processes.
Scale-up of industrial microbial processes.
复制标题
扩大工业微生物过程。
DOI：
10.1093/femsle/fny138
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发表时间：
2018-07-01
影响因子：
2.1
通讯作者：
Lievense JC
中科院分区：
文献类型：
--
作者：
Crater JS;Lievense JC
扩大工业微生物工艺用于商业生产是一项高风险的工作，需要的时间和投资往往超过实验室微生物和工艺开发。遗漏、疏忽和错误可能会给项目带来高昂的代价，甚至是致命的。如果方法得当，可以成功地进行放大。提供了三个指导原则作为基础：以终为始；注重细节；为意外做好准备。详细的路线图建立在这些原则的基础上。特别强调发酵步骤，该步骤通常成本最高，也会影响下游加工。给出了常见的放大错误的示例和推荐的方法。建议从微生物和工艺开发的一开始就利用擅长集成工艺开发和放大的工程资源来指导正在进行的研发，从而确保通往大规模商业终端的顺利且有利可图的道路。扩大工业微生物工艺是一项成本高昂、风险高的工作，如果处理得当，是可以成功执行的。
Scaling up industrial microbial processes for commercial production is a high-stakes endeavor, requiring time and investment often exceeding that for laboratory microbe and process development. Omissions, oversights and errors can be costly, even fatal to the program. Approached properly, scale-up can be executed successfully. Three guiding principles are provided as a basis: begin with the end in mind; be diligent in the details; prepare for the unexpected. A detailed roadmap builds on these principles. There is a special emphasis on the fermentation step, which is usually the costliest and also impacts downstream processing. Examples of common scale-up mistakes and the recommended approaches are given. It is advised that engineering resources skilled in integrated process development and scale-up be engaged from the very beginning of microbe and process development to guide ongoing R&D, thus ensuring a smooth and profitable path to the large-scale commercial end. Scaling up industrial microbial processes is a costly, high-stakes endeavor that can be executed successfully if approached properly.
影响因子：
4.7
作者：
Noorman, Henk J.;Heijnen, Joseph J.
通讯作者：
Heijnen, Joseph J.