Disentangling the developmental origins of a novel phenotype: enhancement versus reversal of environmentally induced gene expression
Disentangling the developmental origins of a novel phenotype: enhancement versus reversal of environmentally induced gene expression
复制标题
解开新表型的发育起源：环境诱导的基因表达的增强与逆转
DOI：
10.1098/rspb.2022.1764
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Pfennig, David W.
中科院分区：
文献类型：
--
作者：
Levis, Nicholas A.;McKay, Daniel J.;Pfennig, David W.
越来越多的证据表明，许多新的特征可能起源于可塑性主导的进化（PLE）。然而，很少有人知道的发展过程，支持PLE，特别是在其早期阶段。一个这样的过程是“表型进化”，它发生在响应环境变化时，生物体在其表型的可变部分上经历调整，以提高其适应性。在这里，我们问，如果环境诱导的基因表达的变化增强或逆转的一种新的，复杂的表型在spadefoot蟾蜍蝌蚪（Spea multiplicata）的表型住宿。比预期更多的基因受到环境和肝脏和大脑中表型调节的影响。然而，尽管表型调节主要逆转了环境诱导的肝组织基因表达变化，但它增强了脑组织中的这些变化。因此，取决于组织，表型调节可以通过逆转基因表达模式来最小化功能破坏，或者通过增强现有表达模式来促进新奇。因此，我们的研究提供了一个新的表型和PLE的初期阶段的发展起源的见解。
Increasing evidence suggests that many novel traits might have originated via plasticity-led evolution (PLE). Yet, little is known of the developmental processes that underpin PLE, especially in its early stages. One such process is ‘phenotypic accommodation’, which occurs when, in response to a change in the environment, an organism experiences adjustments across variable parts of its phenotype that improve its fitness. Here, we asked if environmentally induced changes in gene expression are enhanced or reversed during phenotypic accommodation of a novel, complex phenotype in spadefoot toad tadpoles (Spea multiplicata). More genes than expected were affected by both the environment and phenotypic accommodation in the liver and brain. However, although phenotypic accommodation primarily reversed environmentally induced changes in gene expression in liver tissue, it enhanced these changes in brain tissue. Thus, depending on the tissue, phenotypic accommodation may either minimize functional disruption via reversal of gene expression patterns or promote novelty via enhancement of existing expression patterns. Our study thereby provides insights into the developmental origins of a novel phenotype and the incipient stages of PLE.
登录
查看更多内容
影响因子：
3.4
作者：
Burraco, Pablo;Rendon, Miguel A.;Gomez-Mestre, Ivan
通讯作者：
Gomez-Mestre, Ivan
eco-evo-devo 中的新兴模型系统：对环境敏感的铲足蟾蜍
影响因子：
2.9
作者：
Cris C. Ledón;D. Pfennig
通讯作者：
D. Pfennig
影响因子：
2.7
作者：
PFENNIG, D
通讯作者：
PFENNIG, D
阿尔茨海默病中的脑能量代谢、认知功能和氧化磷酸化下调。
DOI：
--
发表时间：
1996
期刊：
Neurodegeneration
影响因子：
--
作者：
S. Rapoport;K. Hatanpää;D. Brady;K. Chandrasekaran
通讯作者：
K. Chandrasekaran
影响因子：
2.9
作者：
Moczek, Armin P.
通讯作者：
Moczek, Armin P.