Prognostic factors for human papillomavirus-positive and negative oropharyngeal carcinomas.
Prognostic factors for human papillomavirus-positive and negative oropharyngeal carcinomas.
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DOI：
10.1002/lary.27130
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发表时间：
2018-08
期刊：
影响因子：
--
通讯作者：
Fakhry C
中科院分区：
文献类型：
--
作者：
Yin LX;D'Souza G;Westra WH;Wang SJ;van Zante A;Zhang Y;Rettig EM;Ryan WR;Ha PK;Wentz A;Koch W;Eisele DW;Fakhry C
Human papillomavirus (HPV)-positive and negative oropharyngeal squamous cell carcinoma (OPSCC) are distinct disease entities. Prognostic factors specific to each entity have not been adequately explored. Goals for this study were: 1) To determine whether HPV-positive and HPV-negative OPSCCs have distinct prognostic factors, and 2) To explore the prognostic significance of sex and race in OPSCC after HPV stratification Retrospective review of 239 incident OPSCC patients from 1995 to 2012, treated at Johns Hopkins and UCSF. Women and non-White races were oversampled. All analyses were stratified by tumor HPV ISH status. The effects of sex and race on survival were considered in Kaplan Meier and unadjusted and adjusted Cox regression models. 134 (56.1%) OPSCC patients were HPV-positive. On univariate analysis, women had better overall survival than men among HPV-positive (HR=0.47 95%CI: 0.20–1.07, p=0.06) but not HPV-negative (HR=0.73, 95%CI: 0.43–1.24, p=0.24) OPSCCs. On multivariate analysis, women with HPV-positive OPSCCs remained at lower risk of death (aHR=0.34, 95%CI: 0.12–0.96, p=0.04). Survival did not vary significantly by race among HPV-positive patients. Among HPV-negative patients, Hispanic patients had significantly better survival in unadjusted (HR=0.27, 95%CI: 0.08–0.91, p=0.04) but not adjusted (aHR=0.93, 95%CI: 0.11–7.36, p=0.94) analysis. Women with HPV-positive OPSCC may have improved overall survival compared to men. Sex does not play a prognostic role in HPV-negative OPSCC. There are no differences in prognosis by race among HPV-positive or HPV-negative patients.
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影响因子：
1.3
作者：
Cantrell, Sarah C.;Reid, Holly H.;Ginsberg, Lawrence E.
通讯作者：
Ginsberg, Lawrence E.
癌症死亡率和生存中的性别差异。
DOI：
10.1158/1055-9965.epi-11-0246
发表时间：
2011-08
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Cook MB;McGlynn KA;Devesa SS;Freedman ND;Anderson WF
通讯作者：
Anderson WF
影响因子：
4.8
作者：
Guo T;Rettig E;Fakhry C
通讯作者：
Fakhry C
影响因子：
28.4
作者：
D'Souza G;Westra WH;Wang SJ;van Zante A;Wentz A;Kluz N;Rettig E;Ryan WR;Ha PK;Kang H;Bishop J;Quon H;Kiess AP;Richmon JD;Eisele DW;Fakhry C
通讯作者：
Fakhry C
性别，种族和人乳头瘤病毒在口咽和非咽脑颈部和颈部鳞状细胞癌中的预后作用。
影响因子：
6.2
作者：
Fakhry C;Westra WH;Wang SJ;van Zante A;Zhang Y;Rettig E;Yin LX;Ryan WR;Ha PK;Wentz A;Koch W;Richmon JD;Eisele DW;D'Souza G
通讯作者：
D'Souza G