The prognostic role of sex, race, and human papillomavirus in oropharyngeal and nonoropharyngeal head and neck squamous cell cancer.
The prognostic role of sex, race, and human papillomavirus in oropharyngeal and nonoropharyngeal head and neck squamous cell cancer.
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性别，种族和人乳头瘤病毒在口咽和非咽脑颈部和颈部鳞状细胞癌中的预后作用。
DOI：
10.1002/cncr.30353
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发表时间：
2017-05-01
期刊：
影响因子：
6.2
通讯作者：
D'Souza G
中科院分区：
文献类型：
--
作者：
Fakhry C;Westra WH;Wang SJ;van Zante A;Zhang Y;Rettig E;Yin LX;Ryan WR;Ha PK;Wentz A;Koch W;Richmon JD;Eisele DW;D'Souza G
人乳头瘤病毒（HPV）是口咽鳞状细胞癌（OPSCC）的一个公认的预后标志物。由于迄今为止的研究中女性和非白人的数量有限，性别和种族/民族的预后差异尚未得到很好的探讨。在这项研究中，通过肿瘤HPV状态探索了1）按性别和种族划分的OPSCC患者和2）非口咽（非OP）头颈部鳞状细胞癌（HNSCC）患者的生存差异。这项回顾性多机构研究纳入了1995年至2012年诊断的口腔、喉和鼻咽OPSCC和非OP HNSCC。人种/种族分类为非西班牙裔白色白人、非西班牙裔黑人、非西班牙裔亚裔和任何人种的西班牙裔。通过HPV 16 DNA和高危型HPV E6/E7信使RNA原位杂交集中检测肿瘤中p16过表达和HPV的存在。Kaplan-Meier和考克斯比例风险模型用于评估总生存期（OS）。研究人群包括239例OPSCC患者和621例非OP HNSCC患者，中位随访时间为3.5年。在对肿瘤HPV状态、年龄、当前烟草使用和分期进行调整后，女性OPSCC患者的死亡风险低于男性（调整后风险比为0.55; P = 0.04）。结果与p16相似。相比之下，对于非OP HNSCC，HPV阳性，p16阳性和性别与OS无关。对于OPSCC，即使在考虑了肿瘤HPV状态后，性别的生存率也存在差异。对于非OP HNSCC，HPV状态和p16状态没有预后意义。
Human papillomavirus (HPV) is a well-established prognostic marker for oropharyngeal squamous cell cancer (OPSCC). Because of the limited numbers of women and nonwhites in studies to date, sex and racial/ethnic differences in prognosis have not been well explored. In this study, survival differences were explored by the tumor HPV status among 1) patients with OPSCCs by sex and race and 2) patients with nonoropharyngeal (non-OP) head and neck squamous cell cancers (HNSCCs). This retrospective, multi-institution study included OPSCCs and non-OP HNSCCs of the oral cavity, larynx, and nasopharynx diagnosed from 1995 to 2012. Race/ethnicity was categorized as white non-Hispanic, black non-Hispanic, Asian non-Hispanic, and Hispanic of any race. Tumors were centrally tested for p16 overexpression and the presence of HPV by HPV16 DNA and high-risk HPV E6/E7 messenger RNA in situ hybridization. Kaplan-Meier and Cox proportional hazards models were used to evaluate overall survival (OS). The study population included 239 patients with OPSCC and 621 patients with non-OP HNSCC with a median follow-up time of 3.5 years. After adjustments for the tumor HPV status, age, current tobacco use, and stage, the risk of death was lower for women versus men with OPSCC (adjusted hazard ratio, 0.55; P =.04). The results were similar with p16. In contrast, for non-OP HNSCCs, HPV positivity, p16 positivity, and sex were not associated with OS. For OPSCC, there are differences in survival by sex, even after the tumor HPV status has been taken into account. For non-OP HNSCC, the HPV status and the p16 status are not of prognostic significance.
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影响因子：
4.8
作者：
Guo T;Rettig E;Fakhry C
通讯作者：
Fakhry C
DOI：
10.1002/hed.21714
发表时间：
2012-02-01
影响因子：
2.9
作者：
Singhi, Aatur D.;Califano, Joseph;Westra, William H.
通讯作者：
Westra, William H.
癌症死亡率和生存中的性别差异。
DOI：
10.1158/1055-9965.epi-11-0246
发表时间：
2011-08
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Cook MB;McGlynn KA;Devesa SS;Freedman ND;Anderson WF
通讯作者：
Anderson WF
DOI：
10.1002/hed.23318
发表时间：
2014-04
期刊：
Head & neck
影响因子：
--
作者：
Dogan S;Hedberg ML;Ferris RL;Rath TJ;Assaad AM;Chiosea SI
通讯作者：
Chiosea SI
影响因子：
6.2
作者：
Singhi, Aatur D.;Westra, William H.
通讯作者：
Westra, William H.