Purinergic regulation of hypothalamopituitary functions.
Purinergic regulation of hypothalamopituitary functions.
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DOI：
10.1016/j.tem.2009.05.005
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发表时间：
2009-11
影响因子：
10.9
通讯作者：
Stojilkovic, Stanko S.
中科院分区：
文献类型：
--
作者：
Stojilkovic, Stanko S.
下丘脑控制垂体释放激素，并参与控制食物和水的摄入，性行为，生殖，生理状态和行为的日常周期，温度调节和情绪反应。腺苷-5 ′-三磷酸（ATP）及其代谢产物作为腺苷和P2 Y受体以及双跨膜结构域P2 X受体通道的激动剂参与这些功能。本文综述了下丘脑-垂体系统中嘌呤能受体的表达及其在分泌细胞和支持细胞信号转导和细胞功能中的作用。这些组织的ATP分泌，参与ATP水解的酶，以及该途径对受体的顺序激活和信号传导的终止的相关性也进行了讨论。
The hypothalamus controls the release of hormones by the pituitary and is involved in control of food and water intake, sexual behavior, reproduction, and daily cycles in physiological state and behavior, temperature regulation, and emotional responses. Adenosine-5′-triphosphate (ATP) and its metabolic products contribute to these functions, acting as agonists for adenosine and P2Y receptors and two-transmembrane domain P2X receptor channels. This review summarizes the recent findings on purinergic receptor expression and their roles in signaling and cellular function in secretory and supporting cells of the hypothalamo-pituitary system. ATP secretion by these tissues, the enzymes involved in ATP hydrolysis, and the relevance of this pathway for sequential activation of receptors and termination of signaling is also discussed.
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