Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study.
Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study.
复制标题
DOI：
10.1007/s00125-011-2182-9
复制
发表时间：
2011-09
期刊：
影响因子：
8.2
通讯作者：
Wareham, N. J.
中科院分区：
文献类型：
--
作者：
Langenberg, C.;Sharp, S.;Forouhi, N. G.;Franks, P. W.;Schulze, M. B.;Kerrison, N.;Ekelund, U.;Barroso, I.;Panico, S.;Tormo, M. J.;Spranger, J.;Griffin, S.;van der Schouw, Y. T.;Amiano, P.;Ardanaz, E.;Arriola, L.;Balkau, B.;Barricarte, A.;Beulens, J. W. J.;Boeing, H.;Bueno-de-Mesquita, H. B.;Buijsse, B.;Chirlaque Lopez, M. D.;Clavel-Chapelon, F.;Crowe, F. L.;de Lauzon-Guillan, B.;Deloukas, P.;Dorronsoro, M.;Drogan, D.;Froguel, P.;Gonzalez, C.;Grioni, S.;Groop, L.;Groves, C.;Hainaut, P.;Halkjaer, J.;Hallmans, G.;Hansen, T.;Huerta Castano, J. M.;Kaaks, R.;Key, T. J.;Khaw, K. T.;Koulman, A.;Mattiello, A.;Navarro, C.;Nilsson, P.;Norat, T.;Overvad, K.;Palla, L.;Palli, D.;Pedersen, O.;Peeters, P. H.;Quiros, J. R.;Ramachandran, A.;Rodriguez-Suarez, L.;Rolandsson, O.;Romaguera, D.;Romieu, I.;Sacerdote, C.;Sanchez, M. J.;Sandbaek, A.;Slimani, N.;Sluijs, I.;Spijkerman, A. M. W.;Teucher, B.;Tjonneland, A.;Tumino, R.;van der A, D. L.;Verschuren, W. M. M.;Tuomilehto, J.;Feskens, E.;McCarthy, M.;Riboli, E.;Wareham, N. J.
关键词：
研究基因-生活方式的相互作用可能有助于确定改变遗传易感性的生活方式因素，并揭示发挥重要亚组效应的遗传位点。缺乏前瞻性的、无偏见的、标准化的基因-生活方式研究关键行为因素的评估。建立一项2型糖尿病病例队列研究，旨在调查遗传和潜在可改变的生活方式和行为因素，特别是饮食和体力活动，如何相互作用，影响2型糖尿病的发病风险。在第六个欧洲框架计划的资助下，InterAct财团合作伙伴确定并核实了1991年至2007年期间欧洲癌症与营养前瞻性调查（EPIC）队列中发生的2型糖尿病事件病例，这些病例来自10个EPIC国家中的8个。一个务实的，高灵敏度的方法被用于病例确定，包括在每个EPIC中心的多个来源，其次是诊断验证。采用Prentice加权考克斯回归和随机效应荟萃分析研究不同年龄和性别的糖尿病发病率差异。在对符合InterAct标准的340，234名EPIC参与者进行的399万人年随访期间，共发生了12，403例经验证的2型糖尿病事件。我们定义了一个由16,154名个体组成的中心分层子队列进行比较分析。随机选择的糖尿病患者（n=778）作为病例纳入分析。所有流行的糖尿病病例均被排除在研究之外。InterAct病例平均随访6.9年，49.7%为男性。平均基线年龄和诊断时年龄分别为55.6岁和62.5岁，男性的平均BMI和腰围分别为29.4 kg/m2和102.7 cm，女性分别为30.1 kg/m2和92.8 cm。2型糖尿病的风险随年龄线性增加，10岁年龄差异的总体风险比（95%CI）为1.56（1.48; 1.64），经性别校正。在所有国家都一致观察到男性糖尿病发病风险过高，合并风险比为1.51（1.39; 1.64），经年龄校正。InterAct是一项大型的、有力的前瞻性研究，它将使我们了解基因和生活方式因素对2型糖尿病发展风险的相互作用。
Studying gene-lifestyle interaction may help to identify lifestyle factors that modify genetic susceptibility and uncover genetic loci exerting important subgroup effects. Adequately powered studies with prospective, unbiased, standardised assessment of key behavioural factors for gene-lifestyle studies are lacking. To establish a type 2 diabetes case-cohort study designed to investigate how genetic and potentially modifiable lifestyle and behavioral factors, particularly diet and physical activity, interact in their influence on the risk of developing type 2 diabetes. Funded by the Sixth European Framework Programme, InterAct consortium partners ascertained and verified incident cases of type 2 diabetes occurring in European Prospective Investigation into Cancer and Nutrition (EPIC) cohorts between 1991 and 2007 from 8 of the 10 EPIC countries. A pragmatic, high sensitivity approach was used for case ascertainment including multiple sources at each EPIC centre, followed by diagnostic verification. Prentice-weighted Cox regression and random effects meta-analyses were used to investigate differences in diabetes incidence by age and sex. A total of 12,403 verified incident cases of type 2 diabetes occurred during 3.99 million person-years of follow-up of 340,234 EPIC participants eligible for InterAct. We defined a centre stratified subcohort of 16,154 individuals for comparative analyses. Individuals with incident diabetes that were randomly selected into the subcohort (n=778) were included as cases in the analyses. All prevalent diabetes cases were excluded from the study. InterAct cases were followed-up for an average of 6.9 years, 49.7% were men. Mean baseline age and age at diagnosis were 55.6 and 62.5 years, mean BMI and waist were 29.4 kg/m2 and 102.7 cm in men, and 30.1 kg/m2 and 92.8 cm in women, respectively. Risk of type 2 diabetes increased linearly with age, with an overall hazard ratio (95% CI) of 1.56 (1.48; 1.64) for a 10 year age difference, adjusted for sex. A male excess in the risk of incident diabetes was consistently observed across all countries, with a pooled hazard ratio of 1.51 (1.39; 1.64), adjusted for age. InterAct is a large, well powered, prospective study which will inform our understanding of the interplay between genes and lifestyle factors on the risk of type 2 diabetes development.
登录
查看更多内容
影响因子：
4.2
作者：
McCarthy, Mark I.;Zeggini, Eleftheria
通讯作者：
Zeggini, Eleftheria
影响因子：
3.5
作者：
Forouhi, N. G.;Luan, J.;Wareham, N. J.
通讯作者：
Wareham, N. J.
影响因子：
3.5
作者：
Rathmann, W.;Strassburger, K.;Meisinger, C.
通讯作者：
Meisinger, C.
影响因子：
8.2
作者：
Jansson, S. P. O.;Andersson, D. K. G.;Svardsudd, K.
通讯作者：
Svardsudd, K.
影响因子：
3.5
作者：
McCarthy, Mark I.;Hirschhorn, Joel N.
通讯作者：
Hirschhorn, Joel N.