Pathogen-specific regulatory T cells delay the arrival of effector T cells in the lung during early tuberculosis.
Pathogen-specific regulatory T cells delay the arrival of effector T cells in the lung during early tuberculosis.
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DOI：
10.1084/jem.20091885
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发表时间：
2010-07-05
期刊：
影响因子：
--
通讯作者：
Urdahl KB
中科院分区：
文献类型：
--
作者：
Shafiani S;Tucker-Heard G;Kariyone A;Takatsu K;Urdahl KB
激活的 Foxp3+ 调节性 T (T reg) 细胞会阻碍适应性免疫系统限制结核分枝杆菌 (Mtb) 的能力。病原体特异性 T reg 细胞在此过程中的重要性尚未得到解决。我们发现，气溶胶 Mtb 感染后，T reg 细胞不会发生扩增，直到 Mtb 被转运到肺淋巴结 (pLN)，并且 Mtb 特异性 T reg 细胞的增殖倾向增加。即使是少量的 Mtb 特异性 T reg 细胞也能够延迟 pLN 中效应 CD4+ 和 CD8+ T 细胞的启动以及它们随后在肺部（主要感染部位）的积累。这种延迟可能会延长细菌扩张的初始阶段，并解释了在这些小鼠中观察到的更高的细菌负荷。因此，T reg 细胞特异性识别 Mtb 衍生抗原，并有效地限制结核病期间的保护性免疫反应。
The ability of the adaptive immune system to restrict Mycobacterium tuberculosis (Mtb) is impeded by activated Foxp3+ regulatory T (T reg) cells. The importance of pathogen-specific T reg cells in this process has not been addressed. We show that T reg cell expansion after aerosol Mtb infection does not occur until Mtb is transported to the pulmonary lymph node (pLN), and Mtb-specific T reg cells have an increased propensity to proliferate. Even small numbers of Mtb-specific T reg cells are capable of delaying the priming of effector CD4+ and CD8+ T cells in the pLN and their subsequent accumulation in the lung, the primary site of infection. This delay likely prolongs the initial phase of bacterial expansion and explains the higher bacterial burden observed in these mice. Thus, T reg cells recognizing Mtb-derived antigens specifically and potently restrict protective immune responses during tuberculosis.
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