Gold nanoparticle imaging and radiotherapy of brain tumors in mice.
Gold nanoparticle imaging and radiotherapy of brain tumors in mice.
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DOI：
10.2217/nnm.12.165
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发表时间：
2013-10
期刊：
影响因子：
--
通讯作者：
Slatkin DN
中科院分区：
文献类型：
--
作者：
Hainfeld JF;Smilowitz HM;O'Connor MJ;Dilmanian FA;Slatkin DN
目的：测试静脉注射金纳米颗粒对脑内恶性胶质瘤的x线成像和放疗增强作用。通过静脉注射约11纳米大小的金纳米颗粒，并使用微计算机断层扫描对大脑进行成像。静脉注射4 g Au/kg剂量15小时后，用30 Gy 100 kVp x射线照射大脑。金的摄取使肿瘤与正常脑的比例为19:1，肿瘤中金的w/w为1.5%，计算出局部辐射剂量增加了约300%。接受金和辐射（30 Gy）的小鼠显示50%的长期无肿瘤生存（bbb10 - 1年），而所有接受辐射的小鼠仅死亡。静脉注射的金纳米颗粒穿过血脑屏障，但大部分被正常血脑屏障阻挡，从而实现高分辨率的计算机断层扫描肿瘤成像。与单独放疗相比，金放疗增强显著提高了长期生存率。这种方法有望改善人类脑肿瘤和其他癌症的治疗。
To test intravenously injected gold nanoparticles for x-ray imaging and radiotherapy enhancement of large, imminently lethal, intracerebral malignant gliomas. Gold nanoparticles approximately 11 nm in size were injected intravenously and brains imaged using microcomputed tomography. A total of 15 h after an intravenous dose of 4 g Au/kg was administered, brains were irradiated with 30 Gy 100 kVp x-rays. Gold uptake gave a 19:1 tumor-to-normal brain ratio with 1.5% w/w gold in tumor, calculated to increase local radiation dose by approximately 300%. Mice receiving gold and radiation (30 Gy) demonstrated 50% long term (>1 year) tumor-free survival, whereas all mice receiving radiation only died. Intravenously injected gold nanoparticles cross the blood–tumor barrier, but are largely blocked by the normal blood–brain barrier, enabling high-resolution computed tomography tumor imaging. Gold radiation enhancement significantly improved long-term survival compared with radiotherapy alone. This approach holds promise to improve therapy of human brain tumors and other cancers.
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影响因子：
37.3
作者：
Beier D;Schulz JB;Beier CP
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