Monitoring angiogenesis using a human compatible calibration for broadband near-infrared spectroscopy.
Monitoring angiogenesis using a human compatible calibration for broadband near-infrared spectroscopy.
复制标题
使用人类兼容的宽带近红外光谱校准来监测血管生成。
DOI：
10.1117/1.jbo.18.1.016011
复制
发表时间：
2013
影响因子：
3.5
通讯作者：
Dunn,JeffF
中科院分区：
文献类型：
--
作者：
Yang,Runze;Zhang,Qiong;Wu,Ying;Dunn,JeffF
Angiogenesis is a hallmark of many conditions, including cancer, stroke, vascular disease, diabetes, and high-altitude exposure. We have previously shown that one can study angiogenesis in animal models by using total hemoglobin (tHb) as a marker of cerebral blood volume (CBV), measured using broadband near-infrared spectroscopy (bNIRS). However, the method was not suitable for patients as global anoxia was used for the calibration. Here we determine if angiogenesis could be detected using a calibration method that could be applied to patients. CBV, as a marker of angiogenesis, is quantified in a rat cortex before and after hypoxia acclimation. Rats are acclimated at 370-mmHg pressure for three weeks, while rats in the control group are housed under the same conditions, but under normal pressure. CBV increased in each animal in the acclimation group. The mean CBV () is() before acclimation for the experimental group, andafter acclimation. The CBV for the control group is, andfor the two measurements. This demonstrates that angiogenesis can be monitored noninvasively over time using a bNIRS system with a calibration method that is compatible with human use and less stressful for studies using animals.
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影响因子：
15.3
作者：
Moore, M A;Owen, J J
通讯作者：
Owen, J J
影响因子：
5.6
作者：
G. Perah;M. Feldman
通讯作者：
M. Feldman
DOI：
--
发表时间：
1964
期刊：
The Anatomical Record
影响因子：
--
作者：
G. Ackerman;R. A. Knouff
通讯作者：
R. A. Knouff
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5.4
作者：
F. Loor;Heidi Amstutz;L. Hägg;K. S. Mayor;G. Roelants
通讯作者：
G. Roelants
小鼠卵黄囊细胞体外诱导移植物抗宿主反应
影响因子：
5.4
作者：
F. Hofman;A. Globerson
通讯作者：
A. Globerson