Roles of Spermatogonial Stem Cells in Spermatogenesis and Fertility Restoration.
Roles of Spermatogonial Stem Cells in Spermatogenesis and Fertility Restoration.
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DOI：
10.3389/fendo.2022.895528
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发表时间：
2022
影响因子：
5.2
通讯作者：
Reijo Pera, Renee A.
中科院分区：
文献类型：
--
作者：
Diao, Lei;Turek, Paul J.;John, Constance M.;Fang, Fang;Reijo Pera, Renee A.
精原干细胞（spermatogonialstemcells，SSCs）是睾丸中的一组成体干细胞，是精子发生和男性生育的基础。精原干细胞能够自我更新以维持干细胞库的稳定性，并分化产生成熟精子。精原干细胞功能障碍导致男性不育。因此，研究精原干细胞的调控网络对于深入了解精原干细胞在精子发生中的分子机制和男性不育的发病机制具有重要意义。此外，更好地了解SSC生物学将使我们能够在体外培养和分化SSC，这可能为辅助生殖提供新的干细胞治疗。本文综述了精原干细胞调控的最新研究进展，以及精原干细胞在体内外精子发生中的应用前景。我们预计，所获得的知识将促进SSC的应用，以提高男性生育力。此外，从SSC的体外精子发生为从诱导多能干细胞（iPSC）生产SSC和随后的精子发生奠定了基础。
Spermatogonial stem cells (SSCs) are a group of adult stem cells in the testis that serve as the foundation of continuous spermatogenesis and male fertility. SSCs are capable of self-renewal to maintain the stability of the stem cell pool and differentiation to produce mature spermatozoa. Dysfunction of SSCs leads to male infertility. Therefore, dissection of the regulatory network of SSCs is of great significance in understanding the fundamental molecular mechanisms of spermatogonial stem cell function in spermatogenesis and the pathogenesis of male infertility. Furthermore, a better understanding of SSC biology will allow us to culture and differentiate SSCs in vitro, which may provide novel stem cell-based therapy for assisted reproduction. This review summarizes the latest research progress on the regulation of SSCs, and the potential application of SSCs for fertility restoration through in vivo and in vitro spermatogenesis. We anticipate that the knowledge gained will advance the application of SSCs to improve male fertility. Furthermore, in vitro spermatogenesis from SSCs sets the stage for the production of SSCs from induced pluripotent stem cells (iPSCs) and subsequent spermatogenesis.
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影响因子：
1.5
作者：
Forbes CM;Flannigan R;Schlegel PN
通讯作者：
Schlegel PN
影响因子：
3.6
作者：
He, Zuping;Kokkinaki, Maria;Dym, Martin
通讯作者：
Dym, Martin
影响因子：
6
作者：
Alpaugh WF;Voigt AL;Dardari R;Su L;Al Khatib I;Shin W;Goldsmith TM;Coyle KM;Tang LA;Shutt TE;Klein C;Biernaskie J;Dobrinski I
通讯作者：
Dobrinski I
影响因子：
2.9
作者：
Abu Elhija, Mahmoud;Lunenfeld, Eitan;Huleihel, Mahmoud
通讯作者：
Huleihel, Mahmoud
影响因子：
4
作者：
Fischer, S.;Kohlhase, J.;Wieczorek, D.
通讯作者：
Wieczorek, D.