Obesity is associated with reduced cerebral blood flow - modified by physical activity.
Obesity is associated with reduced cerebral blood flow - modified by physical activity.
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DOI：
10.1016/j.neurobiolaging.2021.04.008
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发表时间：
2021-09
影响因子：
4.2
通讯作者：
Kenny RA
中科院分区：
文献类型：
--
作者：
Knight SP;Laird E;Williamson W;O'Connor J;Newman L;Carey D;De Looze C;Fagan AJ;Chappell MA;Meaney JF;Kenny RA
BMI、WHR和腰围增加与脑血流量降低相关。腰围+1cm与脑血流量减少的相关性与年龄+1岁相同。更高水平的体力活动可能会改变这些关联。本研究探讨了老年人的体重指数（BMI）、腰臀比（WHR）、腰围（WC）和体力活动（PA）与灰质脑血流量（CBFGM）的关系。采用爱尔兰老龄化纵向研究的横断面数据（n = 495，年龄69.0 ±7.4岁，52.1%为女性）。使用动脉自旋标记MRI定量全脑CBFGM。多变量回归分析的结果显示，BMI增加0.43 kg/m2，WHR增加0.01，WC增加1.3 cm，CBFGM减少与年龄增加1年相同。报告低/中度PA的BMI超重或WHR/WC高的受试者CBFGM最多降低3 ml/100 g/min（p ≤ .011）;报告高PA的受试者没有显著降低。由于PA可能会减轻肥胖/CBF的相关性，这可能是一种具有成本效益且相对简单的方法，可以帮助减轻肥胖对老年人群的负面影响，例如脑灌注不足，这是血管性痴呆和阿尔茨海默病的早期机制。
Increased BMI, WHR, and waist size associated with lower cerebral blood flow. Waist size +1cm associated with same reduction in cerebral blood flow as +1year age. Higher levels of physical activity shown to potentially modify these associations. This study examined the associations of body mass index (BMI), waist-to-hip ratio (WHR), waist circumference (WC), and physical activity (PA) with gray matter cerebral blood flow (CBFGM) in older adults. Cross-sectional data was used from the Irish Longitudinal Study on Ageing (n = 495, age 69.0 ±7.4 years, 52.1% female). Whole-brain CBFGM was quantified using arterial spin labeling MRI. Results from multivariable regression analysis revealed that an increase in BMI of 0.43 kg/m2, WHR of 0.01, or WC of 1.3 cm were associated with the same reduction in CBFGM as 1 year of advancing age. Participants overweight by BMI or with high WHR/WC reporting low/moderate PA had up to 3 ml/100g/min lower CBFGM (p ≤ .011); there was no significant reduction for those reporting high PA. Since PA could potentially moderate obesity/CBF associations, this may be a cost-effective and relatively easy way to help mitigate the negative impact of obesity in an older population, such as cerebral hypoperfusion, which is an early mechanism in vascular dementia and Alzheimer’s disease.
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